NDLI: Indicator-free electrochemical genosensing originated from the self-signal of poly-xanthurenic acid enhanced by Fe3O4/reduced graphene oxide

Content Provider	Springer Nature Link
Author	Zhang, Wei Wang, Libin Zheng, Xiuwen
Copyright Year	2014
Abstract	In this paper, an indicator-free electrochemical genosensing platform based on the self-signal changes of poly-xanthurenic acid (PXa) enhanced by Fe3O4/reduced graphene oxide (Fe3O4/RGO) was constructed. The resulting nanocomposite (PXa-Fe3O4/RGO) was characterized by transmission electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS). The π–π* stacking and hydrogen bonding between the conjugated Fe3O4/GO and aromatic ring of xanthurenic acid monomer promoted the electropolymerization efficiency accompanied with an increased electrochemical response of PXa. The immobilization of the specific probe DNA was successfully realized via the noncovalent method due to the π–π* interaction between the conjugated nanostructure of PXa-Fe3O4/RGO and DNA bases. The hybridization between the probe DNA and target DNA induced the resulted double-stranded (ds)DNA to be released from the conjugated nanocomposite, accompanied with the self-signal regeneration of nanocomposite (“signal-on”). The self-signal changes could serve as a powerful tool for indicator-free and freely switchable detection of different target genes, and the synergistic effect of the integrated graphene-based nanocomposite effectively improved the sensitivity for the target DNA detection via EIS.
Starting Page	2367
Ending Page	2373
Page Count	7
File Format	PDF
ISSN	14328488
Journal	Journal of Solid State Electrochemistry
Volume Number	18
Issue Number	9
e-ISSN	14330768
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-05-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Indicator-free Electrochemical genosensing Self-signal Poly-xanthurenic acid Fe3O4/reduced graphene oxide Physical Chemistry Electrochemistry Energy Storage Characterization and Evaluation of Materials Analytical Chemistry Condensed Matter Physics
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Materials Science Electrical and Electronic Engineering Electrochemistry

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