NDLI: Representing descriptors derived from multiple conformations as uncertain features for machine learning

Content Provider	Springer Nature Link
Author	rinder, Ulf Boström, Henrik
Copyright Year	2013
Abstract	Uncertainty was introduced into the chemical descriptors of 11 datasets by conformational analysis in order to incorporate three-dimensional information and to investigate the resulting predictive performance of a state-of-the-art machine learning method, random forests, for binary classification tasks. A number of strategies for handling uncertainty in random forests were evaluated. The study showed that when incorporating three-dimensional information as uncertainty into chemical descriptors, the use of uniform probability distributions over the range of possible values, in conjunction with fractional distribution of compounds clearly outperforms the use of normal distributions as well as sampling from both normal and uniform distributions. The main conclusion of this study is that, even when distributions of uncertain values are provided, the random forest method can generate models that are almost as accurate from the expected values of these distributions alone. Hence, there seems to be little advantage to using the more elaborate methods of incorporating uncertainty in chemical descriptors when using random forests rather than replacing the distributions with single-point values. The results also show that random forest models with similar performances can also be generated using three-dimensional descriptor information derived from single (lowest-energy or Corina-derived) conformations. Figure Average accuracy ranks for the five uncertainty methods
Starting Page	2679
Ending Page	2685
Page Count	7
File Format	PDF
ISSN	16102940
Journal	Journal of Molecular Modeling
Volume Number	19
Issue Number	6
e-ISSN	09485023
Language	English
Publisher	Springer-Verlag
Publisher Date	2013-03-12
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Machine learning Random forests Conformational analysis Uncertainty Binary classification Computer Applications in Chemistry Molecular Medicine Computer Application in Life Sciences Characterization and Evaluation of Materials Theoretical and Computational Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Physical and Theoretical Chemistry Computational Theory and Mathematics Catalysis Inorganic Chemistry Computer Science Applications

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