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Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis

Content Provider	Springer Nature Link
Author	Katada, Hitoshi Sei, Hidetake Mizobe, Yasushi Sumaoka, Jun Komiyama, Makoto
Copyright Year	2007
Abstract	The structures of Ce4+ complexes that are active for DNA hydrolysis were determined for the first time by X-ray crystallography. The crystals were prepared from a 1:2 mixture of Ce(NH4)2(NO3)6 and dipicolinic acid (2,6-pyridinedicarboxylic acid). Depending on the recrystallization conditions, three types of crystals were obtained. Some of the Ce4+ ions in these complexes have enough coordinated water molecules that can directly and indirectly participate in the catalysis. The distances between the Ce4+ and the dipicolinate ligand are considerably shorter than those in the corresponding La3+ and Ce3+ complexes. On the other hand, the distances between the Ce4+ and its coordinated water are similar to those for the La3+ and Ce3+ complexes. In a proposed mechanism of DNA hydrolysis, the scissile phosphodiester linkage is notably activated by coordination to Ce4+ and attacked by the Ce4+-bound hydroxide. The process is further assisted by acid catalysis of Ce4+-bound water.
Starting Page	249
Ending Page	255
Page Count	7
File Format	PDF
ISSN	09498257
Journal	JBIC Journal of Biological Inorganic Chemistry
Volume Number	13
Issue Number	2
e-ISSN	14321327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-11-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerium DNA cleavage Phosphodiester hydrolysis Crystal structure Microbiology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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