NDLI: Interaction of apoNeuroglobin with heme–Aβ complexes relevant to Alzheimer’s disease

Content Provider	Springer Nature Link
Author	Seal, Manas Uppal, Sheetal Kundu, Suman Dey, Somdatta Ghosh
Copyright Year	2015
Abstract	Heme–Aβ complexes are known to produce toxic partially reduced oxygen species (PROS), catalyze oxidation of neurotransmitters and have been associated with Alzheimer’s disease (AD). Neuroglobin (Ngb) play a crucial neuroprotective role against oxidative damage, hypoxic injuries, stroke and apoptosis of neuronal cells. In this study, the interaction of heme–Aβ with apoNeuroglobin (apoNgb) has been investigated using a combination of spectroscopic techniques. Absorption and resonance Raman data confirm that apoNgb can uptake heme from heme–Aβ and constitute a six-coordinate low-spin ferric heme-active site identical to that of Ngb. ApoNgb can also uptake heme from reduced heme–Aβ resulting in the formation of ferrous Ngb. The rate of the heme transfer reaction has been found to be of the order of 106 M−1 s−1. The reaction is faster for oxidized heme–Aβ than the reduced form. The amount of PROS formation by heme–Aβ complexes has been found to diminish drastically after reaction with apoNgb. ApoNgb can also sequester ligand-bound heme from heme–Aβ, e.g., the CO-bound heme from heme–Aβ–CO complex resulting in the formation of Ngb–CO complex. Additionally, ApoNgb can sequester heme from self-assembled monolayer (SAM) of surface-bound heme–Aβ formed over Au surface. This heme sequestration by apoNgb from heme–Aβ not only diminishes heme-induced toxicity but more significantly it produces Ngb which has well-documented neuroprotective role and can thereby potentially reduce risks associated with AD.
Starting Page	563
Ending Page	574
Page Count	12
File Format	PDF
ISSN	09498257
Journal	JBIC Journal of Biological Inorganic Chemistry
Volume Number	20
Issue Number	3
e-ISSN	14321327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-02-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Heme–Aβ ApoNeuroglobin Neuroglobin Alzheimer’s disease PROS Biochemistry Microbiology
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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