NDLI: Kinetics and mechanism of the substitution reactions of [PtCl(bpma)]+, [PtCl(gly-met-S,N,N)] and their aqua analogues with l-methionine, glutathione and 5′-GMP

Please wait, while we are loading the content...

Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c

Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases

Probing the role of copper in the biosynthesis of the molybdenum cofactor in Escherichia coli and Rhodobacter sphaeroides

Kinetics and mechanism of the substitution reactions of [PtCl(bpma)]+, [PtCl(gly-met-S,N,N)] and their aqua analogues with l-methionine, glutathione and 5′-GMP

Theoretical investigation on the oxidative chlorination performed by a biomimetic non-heme iron catalyst

Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin: II. Introduction of an O–H···Sγ–Fe hydrogen bond increased the reduction potential by 65 mV

Effect of α-domain substitution on the structure, property and function of human neuronal growth inhibitory factor

Zinc complexes of the biomimetic N,N,O ligand family of substituted 3,3-bis(1-alkylimidazol-2-yl)propionates: the formation of oxalate from pyruvate

Matrix metalloproteinase–inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors

The reaction mechanism of the Ga(III)Zn(II) derivative of uteroferrin and corresponding biomimetics

Validation of density functional modeling protocols on experimental bis(μ-oxo)/μ-η2:η2-peroxo dicopper equilibria

End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes

Theoretical study of the catalytic mechanism of catechol oxidase

Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats

Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor

A note from the President

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 7, September 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 6, August 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 1, Supplement,July 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 5, June 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 4, May 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 3, March 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 2, February 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 1, January 2007

JBIC Journal of Biological Inorganic Chemistry : Volume 11

JBIC Journal of Biological Inorganic Chemistry : Volume 10

JBIC Journal of Biological Inorganic Chemistry : Volume 9

JBIC Journal of Biological Inorganic Chemistry : Volume 8

JBIC Journal of Biological Inorganic Chemistry : Volume 7

JBIC Journal of Biological Inorganic Chemistry : Volume 6

JBIC Journal of Biological Inorganic Chemistry : Volume 5

JBIC Journal of Biological Inorganic Chemistry : Volume 4

JBIC Journal of Biological Inorganic Chemistry : Volume 3

JBIC Journal of Biological Inorganic Chemistry : Volume 2

Kinetics and mechanism of the substitution reactions of [PtCl(bpma)]+, [PtCl(gly-met-S,N,N)] and their aqua analogues with l-methionine, glutathione and 5′-GMP

Content Provider	Springer Nature Link
Author	Bugarčić, Živadin D. Rosić, Jovana Petrović, Biljana Summa, Nadine Puchta, Raph Eldik, Rudi
Copyright Year	2007
Abstract	The substitution reactions of [PtCl(bpma)]+, [PtCl(gly-met-S,N,N)], [Pt(bpma)(H2O)]2+ and [Pt(gly-met-S,N,N)(H2O)]+ [where bpma is bis(2-pyridylmethyl)amine and gly-met-S,N,N is glycylmethionine] with l-methionine, glutathione and guanosine 5′-monophosphate (5′-GMP) were studied in aqueous solutions in 0.10 M NaClO4 under pseudo-first-order conditions as a function of concentration and temperature using UV–vis spectrophotometry. The reactions of the chloro complexes were followed in the presence of 10 mM NaCl and at pH ~ 5, whereas the reactions of the aqua complexes were studied at pH 2.5. The [PtCl(bpma)]+ complex is more reactive towards the chosen nucleophiles than [PtCl(gly-met-S,N,N)]. Also, the aqua complexes are more reactive than the corresponding chloro complexes. The activation parameters for all the reactions studied suggest an associative substitution mechanism. The reactions of [PtCl(bpma)]+ and [PtCl(gly-met-S,N,N)] with 5′-GMP were studied by using 1H NMR spectroscopy at 298 K. The pK a value of the [Pt(gly-met-S,N,N)(H2O)]+ complex is 5.95. Density functional theory calculations (B3LYP/LANL2DZp) show that in all cases guanine coordination to the L3Pt fragment (L3 is terpyridine, bpma, diethylenetriamine, gly-met-S,N,N) is much more favorable than the thioether-coordinated form. The calculations collectively support the experimentally observed substitution of thioethers from Pt(II) complexes by N7-GMP. This study throws more light on the mechanistic behavior of platinum antitumor complexes.
Starting Page	1141
Ending Page	1150
Page Count	10
File Format	PDF
ISSN	09498257
Journal	JBIC Journal of Biological Inorganic Chemistry
Volume Number	12
Issue Number	8
e-ISSN	14321327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-08-21
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Platinum(II) complexes Thioethers Guanosine 5′-monophosphate Kinetics Mechanism Microbiology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Equilibrium and $^{1}$H NMR Kinetic Study of the Reactions of Dichlorido [S-Methyl-L-Cysteine(N,S)]Platinum(II) Complex with Some Relevant Biomolecules

The impact of different chelating leaving groups on the substitution kinetics of mononuclear PtII(1,2-trans-R,R-diaminocyclohexane)(X–Y) complexes

Equilibrium studies on complex formation reactions of dichlorido[(R,R)-trans-1,2-diaminocyclohexane]platinum(II) complex with ligands of biological significance

Cytotoxic properties of platinum(IV) and dinuclear platinum(II) complexes and their ligand substitution reactions with guanosine-5′-monophosphate

Kinetics and mechanism of aqua ligand substitution in cis_diaqua _ethylenediamine_ platinum II perchlorate by bio_active ligands

Complex formation reactions of two sterically hindered platinum(II) complexes with some N-bonding ligands

A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity

Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

A bulky platinum triamine complex that reacts faster with guanosine 5′-monophosphate than with N-acetylmethionine

Kinetics and mechanism of the substitution reactions of [PtCl(bpma)]+, [PtCl(gly-met-S,N,N)] and their aqua analogues with l-methionine, glutathione and 5′-GMP

Similar Documents

Equilibrium and $^{1}$H NMR Kinetic Study of the Reactions of Dichlorido [S-Methyl-L-Cysteine(N,S)]Platinum(II) Complex with Some Relevant Biomolecules

The impact of different chelating leaving groups on the substitution kinetics of mononuclear PtII(1,2-trans-R,R-diaminocyclohexane)(X–Y) complexes

Equilibrium studies on complex formation reactions of dichlorido[(R,R)-trans-1,2-diaminocyclohexane]platinum(II) complex with ligands of biological significance

Cytotoxic properties of platinum(IV) and dinuclear platinum(II) complexes and their ligand substitution reactions with guanosine-5′-monophosphate

Kinetics and mechanism of aqua ligand substitution in cis_diaqua _ethylenediamine_ platinum II perchlorate by bio_active ligands

Complex formation reactions of two sterically hindered platinum(II) complexes with some N-bonding ligands

A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity

Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

A bulky platinum triamine complex that reacts faster with guanosine 5′-monophosphate than with N-acetylmethionine

Kinetics and mechanism of the substitution reactions of [PtCl(bpma)]+, [PtCl(gly-met-S,N,N)] and their aqua analogues with l-methionine, glutathione and 5′-GMP