NDLI: Development of an obidoxime chloride reference material: a metrological approach to the determination of chromatographic purity

Content Provider	Springer Nature Link
Author	Schumacher, Ilana Gorenbein, Paul Raskin, Arthur Kuselman, Ilya
Copyright Year	2007
Abstract	A metrological approach to determination of the chromatographic purity of obidoxime chloride and the corresponding obidoxime chloride reference material (RM) with a certified chromatographic purity value have been developed. This value was defined as the ratio of the sum of peak areas of obidoxime chloride isomers to the total peak area of detected substances including impurities (%) under specified HPLC–UV conditions. The RM homogeneity and stability were studied using HPLC with UV detection and evaluated as satisfactory. The certified value calculated from the results of an interlaboratory trial was equal to 99.9% with the expanded uncertainty of 0.6% at the level of confidence 0.95 and the coverage factor 2. The RM certified value, like other results of chromatographic purity determination traceable to the reference measurement procedure, is not traceable directly to the SI mole. However, the results are comparable in metrologically traceable environments, i.e. when relevant measuring laboratory instruments are calibrated with traceability chains to the corresponding SI units. Therefore, the RM can be used as a measurement standard (calibrator) for analytical instruments and as a control sample for quality control of HPLC obidoxime chloride assay results.
Starting Page	629
Ending Page	636
Page Count	8
File Format	PDF
ISSN	09491775
Journal	Accreditation and Quality Assurance
Volume Number	12
Issue Number	12
e-ISSN	14320517
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-11-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Obidoxime chloride Reference material Chromatographic purity Metrological approach HPLC Marketing Ecotoxicology Commercial Law Biochemistry Food Science Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Instrumentation Chemical Engineering Safety, Risk, Reliability and Quality

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