NDLI: A short review on creatine–creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy

Content Provider	Springer Nature Link
Author	Patra, Subrata Ghosh, Alok Roy, Soumya Sinha Bera, Soumen Das, Manju Talukdar, Dipa Ray, Subhankar Wallimann, Theo Ray, Manju
Copyright Year	2011
Abstract	The creatine/creatine kinase (CK) system plays a key role in cellular energy buffering and transport. In vertebrates, CK has four isoforms expressed in a tissue-specific manner. In the process of creatine biosynthesis several other important metabolites are formed. The anticancer effect of creatine had been reported in the past, and recent literature has reported low creatine content in several types of malignant cells. Furthermore, creatine can protect cardiac mitochondria from the deleterious effects of some anticancer compounds. Previous work from our laboratory showed progressive decrease of phosphocreatine, creatine and CK upon transformation of skeletal muscle into sarcoma. It was convincingly demonstrated that prominent expression of creatine-synthesizing enzymes l-arginine: glycine amidinotransferase and N-guanidinoacetate methyltransferase occurs in sarcoma, Ehrlich ascites carcinoma and sarcoma 180 cells; whereas, both these enzymes are virtually undetectable in skeletal muscle. Creatine transporter also remained unaltered in malignant cells. The anticancer effect of methylglyoxal had been known for a long time. The present work shows that this anticancer effect of methylglyoxal is significantly augmented in presence of creatine. On creatine supplementation the effect of methylglyoxal plus ascorbic acid was further augmented and there was no visible sign of tumor. Moreover, creatine and CK, which were very low in sarcoma tissue, were significantly elevated with the concomitant regression of tumor.
Starting Page	2319
Ending Page	2330
Page Count	12
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	42
Issue Number	6
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2011-07-19
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Ascorbic acid Cancer Creatine Creatine kinase Methylglyoxal Biochemical Engineering Analytical Chemistry Biochemistry Proteomics Life Sciences Neurobiology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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