NDLI: Compatibility of the conformationally rigid CF3-Bpg side chain with the hydrophobic coiled-coil interface

Content Provider	Springer Nature Link
Author	Salwiczek, Mario Mikhailiuk, Pavel K. Afonin, Sergii Komarov, Igor V. Ulrich, Anne S. Koksch, Beate
Copyright Year	2010
Abstract	3-(Trifluoromethyl)bicyclopent-[1.1.1]-1-yl glycine (CF3-Bpg) has previously been established as a useful 19F NMR label to analyse the structures of oligomeric membrane-active peptides or transmembrane segments. To systematically examine the effect of side chain volume, conformational rigidity, and hydrophobicity of CF3-Bpg in polypeptide environments the amino acid was incorporated into an established coiled-coil based screening system. A single substitution of either valine (position a16) or leucine (position d19) within the hydrophobic core of the heteromeric coiled coil has practically no effect on its structure. Despite its comparatively high hydrophobicity, however, the stiff and bulky side chain of CF3-Bpg is not so well accommodated by the hydrophobic core as it leads to a more pronounced destabilization than observed for other, more polar fluorinated amino acids which carry more flexible side chains. CF3-Bpg is therefore a useful 19F NMR label, though not for monitoring the stability of such helix–helix interactions.
Starting Page	1589
Ending Page	1593
Page Count	5
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	39
Issue Number	5
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2010-04-13
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Fluorinated amino acids CF3-Bicyclopentyl glycine α-Helical coiled coil Solid state 19F NMR 19F labelling Neurobiology Proteomics Life Sciences Biochemical Engineering Analytical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A systematic study of fundamentals in α-helical coiled coil mimicry by alternating sequences of β- and γ-amino acids

Domino reactions with fluorinated five-membered heterocycles. α-Trifluoromethyl α-amino acids with unsaturated side-chains

Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues

Heterocyclic Peptide Backbone Modifications in an α-Helical Coiled Coil

Towards identifying preferred interaction partners of fluorinated amino acids within the hydrophobic environment of a dimeric coiled coil peptide

Synthesis of some racemicγ-fluoro-α-amino acids

Advances in the synthesis of α-quaternary α-ethynyl α-amino acids

Synthesis of α-trifluoromethyl α-amino acids with aromatic, heteroaromatic and ferrocenyl subunits in the side chain

(S)-α-methyl,α-amino acids: a new stereocontrolled synthesis

Compatibility of the conformationally rigid CF3-Bpg side chain with the hydrophobic coiled-coil interface

Similar Documents

A systematic study of fundamentals in α-helical coiled coil mimicry by alternating sequences of β- and γ-amino acids

Domino reactions with fluorinated five-membered heterocycles. α-Trifluoromethyl α-amino acids with unsaturated side-chains

Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues

Heterocyclic Peptide Backbone Modifications in an α-Helical Coiled Coil

Towards identifying preferred interaction partners of fluorinated amino acids within the hydrophobic environment of a dimeric coiled coil peptide

Synthesis of some racemicγ-fluoro-α-amino acids

Advances in the synthesis of α-quaternary α-ethynyl α-amino acids

Synthesis of α-trifluoromethyl α-amino acids with aromatic, heteroaromatic and ferrocenyl subunits in the side chain

(S)-α-methyl,α-amino acids: a new stereocontrolled synthesis

Compatibility of the conformationally rigid CF3-Bpg side chain with the hydrophobic coiled-coil interface