NDLI: Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases

Content Provider	Springer Nature Link
Author	Golubnitschaja, O.
Copyright Year	2006
Abstract	Maintenance of genomic integrity is critical for prevention of a wide variety of adverse cellular effects including apoptosis, cellular senescence, and malignant cell transformation. Under stress conditions and even during an unperturbed cell cycle, checkpoint proteins play the key role in genome maintenance by and mediating cellular response to DNA damage, and represent an essential part of the “cellular stress response proteome”. Intact checkpoint signal transduction cascades check the presence of genome damage, trigger cell cycle arrest, and forward the information to the protein core of cell cycle machinery, replication apparatus, repair, and/or apoptotic protein cores. Genetic checkpoint defects lead to syndromes that demonstrate chromosomal instability, increased sensitivity to genotoxic stress, tissue degeneration, developmental retardation, premature aging, and cancer predisposition that is most extensively studied for the ATM-checkpoint mutated in Ataxia telangiectasia. Tissue specific epigenetic control over the function of cell cycle checkpoints can be, further, misregulated by aberrant DNA methylation status. The consequent checkpoint dysregulation may result in tissue specific degenerative processes such as degeneration and calcification of heart aortic valves, diabetic cardiomyopathy, hyperhomocysteinemic cerebrovascular, peripheral vascular and coronary heart diseases, neurodegenerative disorders (Alzheimer and Parkinson diseases, amyotrophic lateral sclerosis, glaucoma), and accelerated aging frequently accompanied with cancer. This review focuses on the checkpoints shown to be crucial for unperturbed cell cycle regulation, dysregulation of which might be considered as a potential molecular marker for early diagnosis of and therapy efficiency in neurodegenerative, cardiovascular and cancer diseases. An application of the most potent detection technologies such as “Disease Proteomics and Transcriptomics” also considered here, allows a most specific selection of diagnostic markers.
Starting Page	359
Ending Page	371
Page Count	13
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	32
Issue Number	3
e-ISSN	14382199
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-11-30
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Biochemistry Analytical Chemistry Biochemical Engineering Life Sciences Proteomics Neurobiology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

γ-Glutamylamines and neurodegenerative diseases

Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases

Critical role of transglutaminase and other stress proteins during neurodegenerative processes

Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer’s disease

Polyamines and their analogs in cancer and other diseases

Creatine kinase in cell cycle regulation and cancer

P21WAF1/CIP1 and 14-3-3 σ gene expression in degenerated aortic valves: A link between cell cycle checkpoints and calcification

Carnosine and cancer: a perspective

Nuclear/cytoplasmic localization of Akt activity in the cell cycle

Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases

Similar Documents

γ-Glutamylamines and neurodegenerative diseases

Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases

Critical role of transglutaminase and other stress proteins during neurodegenerative processes

Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer’s disease

Polyamines and their analogs in cancer and other diseases

Creatine kinase in cell cycle regulation and cancer

P21WAF1/CIP1 and 14-3-3 σ gene expression in degenerated aortic valves: A link between cell cycle checkpoints and calcification

Carnosine and cancer: a perspective

Nuclear/cytoplasmic localization of Akt activity in the cell cycle

Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases