NDLI: Aberrant expression of cytoskeleton proteins in hippocampus from patients with mesial temporal lobe epilepsy

Content Provider	Springer Nature Link
Author	Yang, J. W. Czech, T. Felizardo, M. Baumgartner, C. Lubec, G.
Copyright Year	2006
Abstract	Mesial temporal lobe epilepsy (MTLE), the most common form of epilepsy, is characterised by cytoarchitectural abnormalities including neuronal cell loss and reactive gliosis in hippocampus. Determination of aberrant cytoskeleton protein expression by proteomics techniques may help to understand pathomechanism that is still elusive. We searched for differential expression of hippocampal proteins by an analytical method based on two-dimensional gel electrophoresis (2-DE) coupled with mass spectrometry unambiguously identifying 77 proteins analysed in eight control and eight MTLE hippocampi. Proteins were quantified and we observed 18 proteins that were altered in MTLE. Cytoskeleton proteins tubulin α-1 chain, β-tubulin, profilin II, neuronal tropomodulin were significantly reduced and one actin spot was missing, whereas ezrin and vinculin were significantly increased in MTLE. Proteins of several classes as e.g. antioxidant proteins (peroxiredoxins 3 and 6), chaperons (T-complex protein 1-α, stress-induced-phosphoprotein 1), signaling protein MAP kinase kinase 1, synaptosomal proteins (synaptotagmin I, α-synuclein), NAD-dependent deacetylase sirtuin-2 and 26S protease regulatory subunit 7 protein, neuronal-specific septin 3 were altered in MTLE. Taken together, the findings may represent or lead to cytoskeletal impairment; aberrant antioxidant proteins, chaperons, MAP kinase kinase 1 and NAD-dependent deacetylase sirtuin-2 may have been involved in pathogenetic mechanisms and altered synaptosomal protein expression possibly reflects synaptic impairment in MTLE.
Starting Page	477
Ending Page	493
Page Count	17
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	30
Issue Number	4
e-ISSN	14382199
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-04-04
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Biochemistry Proteomics Neurobiology Life Sciences Analytical Chemistry Biochemical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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