NDLI: Taurine plays an important role in the protection of spermatogonia from oxidative stress

Content Provider	Springer Nature Link
Author	Higuchi, Masato Celi, Fritzie T. Shimizu Yamaguchi, Soko Miura, Chiemi Miura, Takeshi
Copyright Year	2012
Abstract	It has been demonstrated that taurine has various physiological functions in the body. We demonstrated that taurine is abundant in the serum, liver, muscle and testis of the Japanese eel (Anguilla japonica). In the eel testis, taurine is found mainly in spermatogonia and is weakly expressed also in the Sertoli cells. We have further found in the eel testis that taurine is actively accumulated via the sodium/chloride-dependent taurine transporter (TauT; SLC6A6), which is expressed in germ cells. In our current study, the effects of taurine on the anti-oxidant response were examined. Taurine was found to promote the total superoxide dismutase (SOD) activity in the testis. Moreover, our results indicate that taurine does not affect the mRNA levels of copper–zinc (Cu/Zn) SOD or manganese SOD, but promotes the translation of Cu/Zn SOD. Overall, our present data suggest that taurine may modulate Cu/Zn SOD at the translational level and thereby may play an important role in the protection of germ cells from oxidative stress.
Starting Page	2359
Ending Page	2369
Page Count	11
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	43
Issue Number	6
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2012-05-23
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Taurine Cu/Zn SOD Spermatogonia Oxidative stress Japanese eel Neurobiology Life Sciences Proteomics Biochemical Engineering Analytical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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