NDLI: Cytotoxic activity of new racemic and optically active N-phosphonoalkyl bicyclic β-amino acids against human malignant cell lines

Content Provider	Springer Nature Link
Author	Todorov, Petar T. Wesseliva, Diana W. Pavlov, Nikola D. Martinez, Jean Calmes, Monique Naydeva, Emilia D.
Copyright Year	2012
Abstract	The cytotoxic effects of novel racemic and optically active constrained N-phosphonoalkyl bicyclic β-amino acids were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited different concentration-dependent antiproliferative effects against the HT-29, MDA-MB-231, HepG2 and HeLa cell lines after 24 h treatment. The most sensitive cells were the HeLa cells at various concentrations of the four compounds tested. The aminophosphonate 3 exerted the most pronounced antiproliferative effect against the HeLa cells (inhibition of the cell vitality up to 70% at 0.5 mg/ml) and was not toxic to the normal Lep3 cells at lower concentration. Furthermore, the N-phosphonophenyl derivatives 1 and 2 displayed antiproliferative effect against mainly the MDA-MB-231 tumour cells at higher concentration.
Starting Page	1445
Ending Page	1450
Page Count	6
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	43
Issue Number	4
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2012-01-12
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Cytotoxic activity Human tumor cell lines Aminophosphonates N-phosphonoalkyl β-amino acids Proteomics Life Sciences Neurobiology Biochemistry Biochemical Engineering Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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