NDLI: The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase

Content Provider	Springer Nature Link
Author	Nikolic, J. Stojavic, I. Pavlovic, R. Sokolovic, D. Bjelakovic, G. Beninati, S.
Copyright Year	2006
Abstract	The existing interrelation in metabolic pathways of L-arginine to polyamines, nitric oxide (NO) and urea synthesis could be affected in sepsis, inflammation, intoxication and other conditions. The role of polyamines and NO in the toxic effect of mercury chloride on rat liver function was studied. Administration of mercury chloride for 24 h led to significantly elevated plasma activities of Alanine transaminase (ALT) and Aspartate transaminase (AST). Malondyaldehyde (MDA) levels were unaffected (p > 0.05) and arginase activity was significantly decreased (p < 0.05) while nitrate/nitrite production was significantly elevated (p < 0.001) in liver tissue. Polyamine oxidase (PAO) and diamine oxidase (DAO) activities, enzymes involved in catabolism of polyamines, were decreased. L-arginine supplementation to intoxicated rats potentiated the effect of mercury chloride on NO production and it was ineffective on arginase activity.Results obtained in this study show that mercury chloride-induced toxicity leads to abnormally high levels of ALT and AST that may indicate liver damage with the involvement of polyamine catabolic enzymes and NO.
Starting Page	127
Ending Page	131
Page Count	5
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	32
Issue Number	1
e-ISSN	14382199
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-05-15
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Analytical Chemistry Biochemical Engineering Life Sciences Biochemistry Proteomics Neurobiology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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