NDLI: Tuberin, p27 and mTOR in different cells

Content Provider	Springer Nature Link
Author	Burgstaller, S. Rosner, M. Lindengrün, C. Hanneder, M. Siegel, N. Valli, A. Fuchs, C. Hengstschläger, M.
Copyright Year	2008
Abstract	Mutations in the genes TSC1 or TSC2 cause the autosomal dominantly inherited tumor suppressor syndrome tuberous sclerosis, which is characterized by the development of tumors, named hamartomas, in different organs. The TSC gene products, hamartin and tuberin, form a complex, of which tuberin is assumed to be the functional component. Both, hamartin and tuberin have been implicated in the control of the cell cycle by activating the cyclin-dependent kinase inhibitor p27 and in cell size regulation by inhibiting the mammalian target of rapamycin (mTOR) a regulator of the p70 ribosomal protein S6 kinase (p70S6K) and its target the ribosomal protein S6. The tuberin/hamartin complex was shown to protect p27 from protein degradation. Within the mTOR signaling pathway tuberin harbors GTPase activating (GAP) potential toward Rheb, which is a potent regulator of mTOR. In this study, we have analyzed the protein levels of tuberin, p27, cyclin D1, mTOR and phospho mTOR Ser2448 (activated mTOR), S6 and phospho S6 Ser240/244 (activated S6) and as controls α-tubulin and topoisomerase IIβ, in ten different cells, including primary normal cells, immortalized and transformed cell lines.
Starting Page	297
Ending Page	302
Page Count	6
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	36
Issue Number	2
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2008-04-02
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Tuberin p27 mTOR S6 Neurobiology Proteomics Life Sciences Biochemical Engineering Analytical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

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Skp2 inversely correlates with p27 and tuberin in transformed cells

Cytoplasmic/nuclear localization of tuberin in different cell lines

Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236

Tuberin negatively affects BCL-2’s cell survival function

Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244

P70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6

Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells

Leucine nutrition in animals and humans: mTOR signaling and beyond

MTOR phosphorylated at S2448 binds to raptor and rictor

Tuberin, p27 and mTOR in different cells

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Skp2 inversely correlates with p27 and tuberin in transformed cells

Cytoplasmic/nuclear localization of tuberin in different cell lines

Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236

Tuberin negatively affects BCL-2’s cell survival function

Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244

P70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6

Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells

Leucine nutrition in animals and humans: mTOR signaling and beyond

MTOR phosphorylated at S2448 binds to raptor and rictor

Tuberin, p27 and mTOR in different cells