NDLI: Assessing Renal Ischemia/Reperfusion Injury in Mice Using Time-Dependent BOLD and DTI at 9.4 T

Content Provider	Springer Nature Link
Author	Woo, Dong Cheol Kim, Nayoung Lee, Do Wan Song, Youyol Shim, Woo Hyun Choi, Yoonseok Woo, Chul Woong Kim, Sang Tae Kim, Jeong Kon Kim, Kyungwon Ha, Hyun Kwon Lee, Jin Seong
Copyright Year	2015
Abstract	The primary goal of this study was to quantitatively assess regional changes in function and pathophysiological characteristics in renal ischemia/reperfusion (IR)-injured mice and compare data obtained at baseline and following injury. The second goal was to correlate blood oxygenation level-dependent (BOLD) and diffusion tensor imaging (DTI) data obtained in renal IR-injured mice at baseline using time-dependent scans. The analyses were conducted using a mouse model of IR injury. T2, apparent diffusion coefficient (ADC), and fractional anisotropy (FA) values were acquired to pathophysiologically evaluate three renal regions. The T2 values obtained in the renal cortex and medulla demonstrated no significant differences between baseline and after IR injury. According to DTI results, ADC values in both renal regions were significantly lower at 0 h, and then gradually increased within 48 h. The FA values of both renal regions decreased at 0 h, and then gradually increased by 8 h after IR injury. BOLD and DTI correlations were not significant in renal cortex. However, significantly positive correlations were found between baseline and time-dependent data obtained from renal medulla of IR-injured kidneys. Our current findings suggest that magnetic resonance imaging could be used to obtain pathophysiological data from separate renal compartments in IR-injured mice. Hence, BOLD and DTI may also provide functional and pathophysiological data on allograft status following kidney transplant without the need to use a contrast agent.
Starting Page	709
Ending Page	722
Page Count	14
File Format	PDF
ISSN	09379347
Journal	Applied Magnetic Resonance
Volume Number	46
Issue Number	6
e-ISSN	16137507
Language	English
Publisher	Springer Vienna
Publisher Date	2015-04-07
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Solid State Physics Spectroscopy/Spectrometry Atoms and Molecules in Strong Fields, Laser Matter Interaction Physical Chemistry Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluation of Disease Stage of Radiation-Induced Brain Injury: a DTI Study with Pathological Correlation

Rapid T 1–T 2 Measurement Using Drive Equilibrium Pulse Sequence

Spin-Dependent Phenomena in Semiconductors and Semiconductor/Ferromagnetic Heterostructures

Developing DNP/Solid-State NMR Spectroscopy of Oriented Membranes

Thoughts on Aging

ONP Spectroscopy of Defects in Silicon

Compact NMR Spectroscopy with Shift Reagents

High-Frequency EPR Instrumentation

NMR in Life Sciences

Assessing Renal Ischemia/Reperfusion Injury in Mice Using Time-Dependent BOLD and DTI at 9.4 T

Similar Documents

Evaluation of Disease Stage of Radiation-Induced Brain Injury: a DTI Study with Pathological Correlation

Rapid T 1–T 2 Measurement Using Drive Equilibrium Pulse Sequence

Spin-Dependent Phenomena in Semiconductors and Semiconductor/Ferromagnetic Heterostructures

Developing DNP/Solid-State NMR Spectroscopy of Oriented Membranes

Thoughts on Aging

ONP Spectroscopy of Defects in Silicon

Compact NMR Spectroscopy with Shift Reagents

High-Frequency EPR Instrumentation

NMR in Life Sciences

Assessing Renal Ischemia/Reperfusion Injury in Mice Using Time-Dependent BOLD and DTI at 9.4 T