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| Content Provider | Springer Nature Link |
|---|---|
| Author | López Lluch, G. Blázquez, M. V. Pérez Vicente, R. Macho, A. Burón, M. I. Alcaín, F. J. Muñoz, E. Navas, P. |
| Copyright Year | 2001 |
| Abstract | Ascorbate has been related to the differentiation of several mesenchymal cells including haematopoietic cells. We have previously demonstrated that ascorbate enhances the activity of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) on monocytic differentiation of HL-60 cells. Here, we show that ascorbate-mediated modification of cellular redox state and AP-1 (activating protein-1) DNA binding during early phases are related to the enhancing effect of ascorbate on differentiation. Ascorbate, but not its fully oxidized form, dehydroascorbate, or an ascorbate analogue with a low rate of oxidation, ascorbate-2-phosphate, enhanced the differentiation induced by 1α,25(OH)2D3, modified cytosolic reactive oxygen species levels and mitochondrial redox potential (ΔΨm), and modulated AP-1 DNA binding in HL-60 cells. Ascorbate itself increased AP-1 binding to DNA in noninduced cells, whereas it inhibited AP-1 binding in 1α,25(OH)2D3-induced cells. However, ascorbate increased the mRNA levels ofc-jun, junB. andc-fos in 1α,25(OH)2D3-induced cells. Taken together, these results suggest that the enhancing effect of ascorbate on HL-60 differentiation induced by 1α,25(OH)2D3 is related to its effect on the cellular redox state and the modulation of AP-1 activity. |
| Starting Page | 129 |
| Ending Page | 136 |
| Page Count | 8 |
| File Format | |
| ISSN | 0033183X |
| Journal | Protoplasma |
| Volume Number | 217 |
| Issue Number | 1-3 |
| e-ISSN | 16156102 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2001-01-01 |
| Publisher Place | Vienna |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Leukemia Cell differentiation Ascorbic acid Vitamin D Activating protein-1 Redox regulation Cell Biology Plant Sciences Zoology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Plant Science Medicine |
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