NDLI: NF-κB activation by CD26 antigen is independent of dipeptidyl peptidase IV activity

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Protoplasma : Volume 196

NF-κB activation by CD26 antigen is independent of dipeptidyl peptidase IV activity

Content Provider	Springer Nature Link
Author	Blàzquez, M. V. Ortiz, C. Aranda, E. Collantes, E. Israël, A. Muñoz, E.
Copyright Year	1997
Abstract	CD26 antigen distribution among lymphoid and non lymphoid cells is widely documented. This antigen contains dipeptidyl peptidase IV (DPP-IV) enzymatic activity and it is thought to play an important role in the processes of cellular activation. We show that cell activation through the CD26 pathway induces DNA binding of the NF-κB/rel family of transcription factors in human peripheral T lymphocytes, in the hepatoma cell line HepG2, and in Hela cells. The functional significance of the NF-κB in the CD26 mediated signal transduction pathway is demonstrated by transient transfection analysis, since treatment of HepG2 and Hela cells with the anti-CD26 monoclonal antibodies 134-2C2 and 1F7 resulted in transactivation of a luciferase reported construct driven by three κB sites. The ability of CD26 to activate NF-κB seems to be independent of its DPP-IV activity but it is likely that CD26 activation results in an increase of intracellular levels of reactive oxygen intermediates as deduced from the antioxidant pyrrolidine dithiocarbamate blocking of the induction of NF-κB activity on CD26 activated cells. These results provide new evidence that the CD26 antigen plays a pivotal role in the mechanisms of activation of CD26 expressing cells.
Starting Page	26
Ending Page	33
Page Count	8
File Format	PDF
ISSN	0033183X
Journal	Protoplasma
Volume Number	197
Issue Number	1-2
e-ISSN	16156102
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-01-01
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CD26 antigen Dipeptidyl peptidase IV NF-κB transcription factor Tumor cells Cell Biology Plant Sciences Zoology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Plant Science Medicine

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