NDLI: Synthesis of Enantiomerically Pure 2-Isoxacephems

Content Provider	Springer Nature Link
Author	Sánta, Zsuzsanna Nagy, József Párkányi, László Nyitrai, József
Copyright Year	2004
Abstract	(αR,6R,7R)-7-(1-Acetoxyethyl)-3-methyl-2-isoxacephem-4-carboxylic acid and its enantiomer have been prepared. The ring systems were formed from the corresponding enantiomerically pure N-unsubstituted β-lactams. The reduction of methyl [(αR,2S,3R)-3-(1-acetoxyethyl)-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylate] has been solved via a hemi-acetal. The structure and the configuration of a new stereogenic center in this intermediate was predicted by using 2D NMR technique and unambiguously proven by x-ray.
Starting Page	671
Ending Page	684
Page Count	14
File Format	PDF
ISSN	00269247
Journal	Monatshefte für Chemie - Chemical Monthly
Volume Number	135
Issue Number	6
e-ISSN	14344475
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-02-05
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Chemistry

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Synthesis of Enantiomerically Pure 2-Isoxacephems