NDLI: A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 4

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A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 4

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A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 4

Content Provider	Springer Nature Link
Author	Haschke, Heinz
Copyright Year	2003
Abstract	In previous papers a strongly simplified physical-mathematical (biokinetic) model has been presented, which dealt with the factors influencing the timely development of DNA mismatches dependent cells (malignant cells) in their kinetic competition to the development of normal somatic cells (i.e. cells with correct genetic information). The kinetic results have been studied by comparing them with experimental results reported in the literature upon inhibiting the organism’s own enzymatic DNA-proofreading and repair machinery. In spite of the fact that the model uses fully the chances of kinetics, which allows to describe even rather complicated systems with many regulation circuits and feed back loops in a rather simple, summarizing way, it has been demonstrated that the model does not only well describe the experimentally found significant increases of mutants in cases when the DNA repair system has been inhibited, but it can also reflect cancer-development and the efficacy of classical cancer therapies like surgery or chemotherapy as well.In applying the predictions of the model as to the opposite of an inhibition of the DNA repair system, i.e., in testing the results, if the organism’s own repair systems were stimulated, the model shows that there could be a chance for a new, adjuvant cancer-therapy if this concept was combined with biochemical facts and clinical findings which are reported in the literature.In continuation of this concept, the predictions of the model have been compared with findings upon cancer-therapies by apoptosis-triggerers like tamoxifen. Further, according to the fact that there exists literature by which it is demonstrated by clinical facts that it is not necessary to use living cells (e.g. from umbilical cord’s blood or bone-marrow) to achieve surprising therapeutic successes in cancer therapy, but also cell-free “human-placenta-extracts” (HPEs) can be similarily effective, it has been tried in a first preliminary analytical effort to characterize “effector-substances” contained therein.
Starting Page	1289
Ending Page	1309
Page Count	21
File Format	PDF
ISSN	00269247
Journal	Monatshefte für Chemie - Chemical Monthly
Volume Number	134
Issue Number	9
e-ISSN	14344475
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Chemistry

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A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 2. Calibration of the Model

A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 3. Application of the Model-1

Repair of DNA Dewar Photoproduct to (6-4) Photoproduct in (6-4) Photolyase

Combining self-healing and proofreading in self-assembly

Long-lasting H-reflex inhibition evoked by stimulation of a nerve to the antagonist muscles and vibrational stimulation of the muscle receptors in humans

Stimulation-induced behavioral inhibition: A new model for understanding physical violence

A biokinetic model for nickel released from cardiovascular devices.

DNA repair: a new tool to target DNA repair.

Physicochemical Mechanism of Light-Driven DNA Repair by (6-4) Photolyases

A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 4

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A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 2. Calibration of the Model

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A Biokinetic Model to Describe Consequences of Inhibition/Stimulation in DNA-Proofreading and -Repair, Part 4