NDLI: The Saunders-Bell Analysis of Tunnel Effects in Reactions with Kinetic Isotope Effects

Content Provider	Springer Nature Link
Author	Leskovac, Vladimir Trivić, Svetlana Pericčin, Draginja Kandrač, Julijan
Copyright Year	2004
Abstract	The primary kinetic isotope effects of deuterium were investigated in 22 hydrogen and deuterium transfer reactions, including enzymatic and nonenzymatic hydride transfer reactions, elimination reactions, and reactions catalyzed by enzymes lipooxygenase, amine dehydrogenase, and methylmalonyl-CoA mutase. In each case, the Saunders-Bell analysis was applied to calculate the tunnel effects and the corresponding thermodynamic parameters. The Saunders-Bell analysis was effective in 14 cases out of 22. A high degree of correlation was found between the barrier factor, the tunnel factor, and the entropy factor among all reactions studied. From this, a general relationship between the three factors was derived, based on the Saunders-Bell analysis of the Bell equation; the Saunders-Bell analysis is valid within certain limits of the barrier factor. This general relationship is universally valid for all hydrogen/deuterium transfer reactions in nature with moderate tunneling, when the Saunders-Bell analysis applies.
Starting Page	1359
Ending Page	1372
Page Count	14
File Format	PDF
ISSN	00269247
Journal	Monatshefte für Chemie - Chemical Monthly
Volume Number	135
Issue Number	11
e-ISSN	14344475
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-06-02
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chemistry/Food Science Analytical Chemistry Inorganic Chemistry Organic Chemistry Physical Chemistry Theoretical and Computational Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry

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