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| Content Provider | Springer Nature Link |
|---|---|
| Author | Amr, Abd El Galil E. Mohamed, Salwa F. Abdel Hafez, Naglaa A. Abdalla, Mohamed M. |
| Copyright Year | 2008 |
| Abstract | A series of oxadiazole pyridine derivatives were synthesized by using 2-chloro-6-hydrazinoisonicotinic acid hydrazide as starting material. Treatment of the hydrazide with carbon disulfide to afford the oxadiazole derivative, which was treated with 5-methyl-2-furancarbaldehyde, formic acid, acetic acid/acetic anhydride, or phthalic anhydride to yield the corresponding pyridinodiazoles and on imide. Condensation of the hydrazide with p-fluorobenzaldehyde in ethanol or acetic acid in the presence of sodium acetate afforded hydrazone and oxadiazole derivatives, which were acetylated and cyclized with acetic anhydride to N-acetyloxadiazole derivatives. The hydrazone was treated with acetic acid in the presence of sodium acetate, or bromine water/sodium acetate to give on oxadiazole, while it was cyclized with chloroacetyl chloride in the presence of TEA to oxoazetidinaminoisonicotinamide. Finally, condensation of the hydrazide with acid anhydrides in refluxing glacial acetic acid afforded the corresponding bisimide derivatives. The pharmacological screening showed that many of these obtained compounds have good antianexiety activity comparable to diazepam® as positive control. |
| Starting Page | 1491 |
| Ending Page | 1498 |
| Page Count | 8 |
| File Format | |
| ISSN | 00269247 |
| Journal | Monatshefte für Chemie - Chemical Monthly |
| Volume Number | 139 |
| Issue Number | 12 |
| e-ISSN | 14344475 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2008-08-06 |
| Publisher Place | Vienna |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | 2-Chloro-6-hydrazinoisonicotinic acid hydrazide; Substituted pyridine; Oxadiazole; Oxoazetidine; Antianexiety activity. Chemistry/Food Science Analytical Chemistry Inorganic Chemistry Organic Chemistry Physical Chemistry Theoretical and Computational Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
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