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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lazo, Laura Gil, Lázaro Lopez, Carlos Valdes, Iris Marcos, Ernesto Álvarez, Mayling Blanco, Aracelys Romero, Yaremis Falcon, Viviana Guzmán, María G. Guillén, Gerardo Hermida, Lisset |
| Copyright Year | 2010 |
| Abstract | In this study, we evaluate in mice a novel formulation containing nucleocapsid-like particles of dengue-2 virus (recNLP) co-immunized with a chimeric protein composed of the dengue-4 envelope domain III fused twice within the meningococcal P64k protein of Neisseria meningitidis (PD24). The animals receiving the PD24–recNLP mixture showed the highest levels of antiviral antibodies. Similar results were obtained for IFNγ secretion levels, indicating a functional Th1 cellular response. Consistently, the percentage of mice surviving after viral challenge was significantly higher for those immunized with the mixture than for those inoculated with PD24 protein alone. In addition, in vivo depletion experiments demonstrated the decisive role of CD4+ and CD8+ cells in the protection conferred by immunization with PD24–recNLP. In conclusion, this report demonstrates for the first time the adjuvant capacity of dengue-2 virus recNLP. Additionally, the evidence presented highlights the potential of these particles for enhancing the immune response against heterologous recombinant proteins. |
| Starting Page | 1587 |
| Ending Page | 1595 |
| Page Count | 9 |
| File Format | |
| ISSN | 03048608 |
| Journal | Archives of Virology |
| Volume Number | 155 |
| Issue Number | 10 |
| e-ISSN | 14328798 |
| Language | English |
| Publisher | Springer Vienna |
| Publisher Date | 2010-07-18 |
| Publisher Place | Vienna |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Infectious Diseases Medical Microbiology Virology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Medicine |
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