NDLI: Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia

Content Provider	Springer Nature Link
Author	Okazaki, K. Takada, A. Ito, T. Imai, M. Takakuwa, H. Hatta, M. Ozaki, H. Tanizaki, T. Naga, T. Nimiya, A. Demenev, V. A. Tyaptirgav, M. M. Karatayeva, T. D. Yamnikova, S. S. Lvov, D. K. Kida, H.
Copyright Year	2000
Abstract	Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in summer from 1996 to 1998. Phylogenetic analysis of the NP genes of the isolates in Siberia and those in Hokkaido, Japan on their flyway of migration from Siberia to the south in autumn revealed that they belong to the Eurasian lineage of avian influenza viruses. It is noted that the genes of the isolates in Siberia are closely related to those of H5N1 influenza virus strains isolated from chickens and humans in Hong Kong in 1997 as well as to those of isolates from domestic birds in southern China. The results indicate that influenza viruses perpetuated in ducks nesting in Siberia should have contributed genes in the emergence of the H5N1 virusin Hong Kong. Vaccine prepared from avirulent A/duck/Hokkaido/4/96 (H5N3) influenza virus was potent enough to protect mice from challenge with lethal dose of the pathogenic H5N1 virus [19]. Intensive surveillance study of aquatic birds especially in Siberia is, therefore, stressed to provide information on the future pandemic influenza virus strains and for vaccine preparation.
Starting Page	885
Ending Page	893
Page Count	9
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	145
Issue Number	5
e-ISSN	14328798
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-05-01
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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