NDLI: Host-cell-dependent role of actin cytoskeleton during the replication of a human strain of influenza A virus

Content Provider	Springer Nature Link
Author	Arcangeletti, M. C. Conto, F. Ferraglia, F. Pinardi, F. Gatti, R. Orlandini, G. Covan, S. Motta, F. Rodighiero, I. Dettori, G. Chezzi, C.
Copyright Year	2008
Abstract	This study was aimed at investigating the possible involvement of the actin cytoskeleton in the modulation of host permissiveness to A/NWS/33 human influenza virus infection in two mammalian (MDCK and LLC-MK2) cell lines in vitro. During the early stages of infection, no appreciable association between incoming NWS/33 virions and cortical actin was detectable in the permissive MDCK model by confocal microscopy, while extensive colocalization and a slower infection progression were observed in LLC-MK2 cells. In the latter model, we also demonstrated the inability of the virus to carry out multiple replication cycles, irrespective of the presence of cleaved HA subunits in the released virions. Treatment with the actin-depolymerizing agent cytochalasin D significantly increased the infection efficiency in LLC-MK2 cells, while a detrimental effect was observed in the MDCK cell line. Our data suggest a selective role of the actin network in inducing a restriction to influenza virus replication, mostly depending on its molecular organization, the host cell type and virus replication phase.
Starting Page	1209
Ending Page	1221
Page Count	13
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	153
Issue Number	7
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2008-05-17
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infectious Diseases Medical Microbiology Virology
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Endogenous protease-dependent replication of human influenza viruses in two MDCK cell lines

Characterization of the host cell entry of filamentous influenza virus

The role of actin filaments in ascovirus replication and pathology

Inhibition of influenza A virus replication by short double-stranded oligodeoxynucleotides

The interplay between Araçatuba virus and host signaling pathways: role of PI3K/Akt in viral replication

Characterisation of an avian influenza A virus isolated from a human – is an intermediate host necessary for the emergence of pandemic influenza viruses?

The cell receptor level is reduced during persistent infection with influenza C virus

The role of microRNAs in hepatitis C virus RNA replication

Interplay between influenza A virus and host factors: targets for antiviral intervention

Host-cell-dependent role of actin cytoskeleton during the replication of a human strain of influenza A virus

Similar Documents

Endogenous protease-dependent replication of human influenza viruses in two MDCK cell lines

Characterization of the host cell entry of filamentous influenza virus

The role of actin filaments in ascovirus replication and pathology

Inhibition of influenza A virus replication by short double-stranded oligodeoxynucleotides

The interplay between Araçatuba virus and host signaling pathways: role of PI3K/Akt in viral replication

Characterisation of an avian influenza A virus isolated from a human – is an intermediate host necessary for the emergence of pandemic influenza viruses?

The cell receptor level is reduced during persistent infection with influenza C virus

The role of microRNAs in hepatitis C virus RNA replication

Interplay between influenza A virus and host factors: targets for antiviral intervention

Host-cell-dependent role of actin cytoskeleton during the replication of a human strain of influenza A virus