NDLI: Amoebas as mimivirus bunkers: increased resistance to UV light, heat and chemical biocides when viruses are carried by amoeba hosts

Content Provider	Springer Nature Link
Author	Boratto, Paulo V. M. Dornas, Fábio P. Andrade, Kétyllen R. Rodrigues, Rodrigo Peixoto, Felipe Silva, Lorena C. F. Scola, Bernard Costa, Adriana Oliveira Almeida, Gabriel Mag Freitas Kroon, Erna G. Abrahão, Jônatas S.
Copyright Year	2013
Abstract	Amoebas of the genus Acanthamoeba are protists that are associated with human disease and represent a public health concern. They can harbor pathogenic microorganisms, acting as a platform for pathogen replication. Acanthamoeba polyphaga mimivirus (APMV), the type species of the genus Mimivirus, family Mimiviridae, represents the largest group of amoeba-associated viruses that has been described to date. Recent studies have demonstrated that APMV and other giant viruses may cause pneumonia. Amoebas can survive in most environments and tolerate various adverse conditions, including UV light irradiation, high concentrations of disinfectants, and a broad range of temperatures. However, it is unknown how the amoebal intracellular environment influences APMV stability and resistance to adverse conditions. Therefore, in this work, we evaluated the stability of APMV, either purified or carried by the amoeba host, under extreme conditions, including UV irradiation, heat and exposure to six different chemical biocides. After each treatment, the virus was titrated in amoebas using the TCID50 method. APMV was more stable in all resistance tests performed when located inside its host. Our results demonstrate that Acanthamoeba acts as a natural bunker for APMV, increasing viral resistance to extreme physical and chemical conditions. The data raise new questions regarding the survival of APMV in nature and in hospital environments.
Starting Page	1039
Ending Page	1043
Page Count	5
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	159
Issue Number	5
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2013-11-26
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Giant Viruses of Amoebas: An Update

Oysters as hot spots for mimivirus isolation

Testing thermal resistance of viruses

Comparison of biological characteristics of H9N2 avian influenza viruses isolated from different hosts

Looking at protists as a source of pathogenic viruses.

Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries

Prokaryote viruses studied by electron microscopy

Relevance of free-living amoebae as hosts for phylogenetically diverse microorganisms

Screening pneumonia patients for mimivirus.

Amoebas as mimivirus bunkers: increased resistance to UV light, heat and chemical biocides when viruses are carried by amoeba hosts

Similar Documents

Giant Viruses of Amoebas: An Update

Oysters as hot spots for mimivirus isolation

Testing thermal resistance of viruses

Comparison of biological characteristics of H9N2 avian influenza viruses isolated from different hosts

Looking at protists as a source of pathogenic viruses.

Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries

Prokaryote viruses studied by electron microscopy

Relevance of free-living amoebae as hosts for phylogenetically diverse microorganisms

Screening pneumonia patients for mimivirus.

Amoebas as mimivirus bunkers: increased resistance to UV light, heat and chemical biocides when viruses are carried by amoeba hosts