NDLI: Detection and molecular identification of leishmania RNA virus (LRV) in Iranian Leishmania species

Content Provider	Springer Nature Link
Author	Hajjaran, Homa Mahdi, Maryam Mohebali, Mehdi Samimi Rad, Katayoun Ataei Pirkooh, Angila Kazemi Rad, Elham Naddaf, Saied Reza Raoofian, Reza
Copyright Year	2016
Abstract	Leishmania RNA virus (LRV) was first detected in members of the subgenus Leishmania (Viannia), and later, the virulence and metastasis of the New World species were attributed to this virus. The data on the presence of LRV in Old World species are confined to Leishmania major and a few Leishmania aethiopica isolates. The aim of this study was to survey the presence of LRV in various Iranian Leishmania species originating from patients and animal reservoir hosts. Genomic nucleic acids were extracted from 50 cultured isolates belonging to the species Leishmania major, Leishmania tropica, and Leishmania infantum. A partial sequence of the viral RNA-dependent RNA polymerase (RdRp) gene was amplified, sequenced and compared with appropriate sequences from the GenBank database. We detected the virus in two parasite specimens: an isolate of L. infantum derived from a visceral leishmaniasis (VL) patient who was unresponsive to meglumine antimoniate treatment, and an L. major isolate originating from a great gerbil, Rhombomys opimus. The Iranian LRV sequences showed the highest similarities to an Old World L. major LRV2 and were genetically distant from LRV1 isolates detected in New World Leishmania parasites. We could not attribute treatment failure in VL patient to the presence of LRV due to the limited number of specimens analyzed. Further studies with inclusion of more clinical samples are required to elucidate the potential role of LRVs in pathogenesis or treatment failure of Old World leishmaniasis.
Starting Page	3385
Ending Page	3390
Page Count	6
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	161
Issue Number	12
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2016-09-07
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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