NDLI: Phenotypic and genotypic characterization of dengue virus isolates differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome

Content Provider	Springer Nature Link
Author	Tuiskunen, Anne Monteil, Vanessa Plumet, Sébastien Boubis, Laetitia Wahlström, Maria Duong, Veasna Buchy, Philippe Lundkvist, Åke Tolou, Hugues Leparc Goffart, Isabelle
Copyright Year	2011
Abstract	Dengue viruses (DENV) cause 50-100 million cases of acute febrile disease every year, including 500,000 reported cases of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Viral factors have been proposed to influence the severity of the disease, but markers of virulence have never been identified on DENV. Three DENV serotype-1 isolates from the 2007 epidemic in Cambodia that are derived from patients experiencing the various clinical forms of dengue were characterized both phenotypically and genetically. Phenotypic characteristics in vitro, based on replication kinetics in different cell lines and apoptosis response, grouped isolates from DF and DHF patients together, whereas the virus isolate from a DSS patient showed unique features: a lower level of replication in mammalian cells and extensive apoptosis in mosquito cells. Genomic comparison of viruses revealed six unique amino acid residues in the membrane, envelope, and in non-structural genes in the virus isolated from the DSS patient.
Starting Page	2023
Ending Page	2032
Page Count	10
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	156
Issue Number	11
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2011-09-16
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medical Microbiology Virology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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