NDLI: Prevalence and genetic characterization of respiratory syncytial virus (RSV) in hospitalized children in Korea

Content Provider	Springer Nature Link
Author	Baek, Yun Hee Choi, Eun Hye Song, Min Suk Pascua, Philippe riel Q. Kwon, Hyeok il Park, Su Jin Lee, Jun Han Woo, Sung Il Ahn, Byung Hoon Han, Heon Seok Hahn, Yoon Soo Shin, Kyeong Seob Jang, Hae Lan Kim, Seok Yong Choi, Young Ki
Copyright Year	2012
Abstract	Human respiratory syncytial virus (HRSV) is the most common respiratory pathogen among infants and young children. To investigate the prevalence and genetic characteristics of HRSVs circulating in South Korea, we analyzed medical records of patients and performed molecular analysis of the G-protein gene of viruses detected from nasopharyngeal aspirates (NPA) of admitted patients at the Pediatrics Department of Chungbuk National University Hospital from April 2008 to April 2010. Epidemiological data revealed that the prevalence of HRSV infection was high during both winter seasons (October 2008 to February 2009 and November 2009 to February 2010). Of the 297 positive NPA specimens from infants or children tested, 67% were identified as HRSV-A while 33% were HRSV-B. The HRSV subgroup B was the most dominant in December 2008, but its dominance was dramatically replaced by HRSV subgroup A strains by February 2009. Phylogenetic analysis of the G protein sequences of HRSVs revealed novel genotypes within the HRSV-A (genotype CB-A) and B (genotypes BA11 and CB-B) subgroups in South Korea in addition to other strains identified in other countries. Molecular analysis also revealed genetic variability at the C-terminal end of the G proteins of the two HRSV subgroups, suggesting selection pressure in this region, which may potentially impact immune recognition. This is the first report of these HRSV variants in South Korea, indicating active genetic evolution of HRSV strains. Therefore, this study provides information on the molecular epidemiology of current HRSVs in the country and presents data for comparative analysis with other HRSV strains circulating worldwide.
Starting Page	1039
Ending Page	1050
Page Count	12
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	157
Issue Number	6
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2012-03-09
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Infectious Diseases Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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