NDLI: Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains

Content Provider	Springer Nature Link
Author	Mostafa, Ahmed Abdelwhab, El Sayed M. Slanina, Heiko Hussein, Mohamed A. Kuznetsova, Irina Schüttler, Christian G. Ziebuhr, John Pleschka, Stephan
Copyright Year	2016
Abstract	Infections by H3N2-type influenza A viruses (IAV) resulted in significant numbers of hospitalization in several countries in 2014-2015, causing disease also in vaccinated individuals and, in some cases, fatal outcomes. In this study, sequence analysis of H3N2 viruses isolated in Germany from 1998 to 2015, including eleven H3N2 isolates collected early in 2015, was performed. Compared to the vaccine strain A/Texas/50/2012 (H3N2), the 2015 strains from Germany showed up to 4.5 % sequence diversity in their HA1 protein, indicating substantial genetic drift. The data further suggest that two distinct phylogroups, 3C.2 and 3C.3, with 1.6-2.3 % and 0.3-2.4 % HA1 nucleotide and amino acid sequence diversity, respectively, co-circulated in Germany in the 2014/2015 season. Distinct glycosylation patterns and amino acid substitutions in the hemagglutinin and neuraminidase proteins were identified, possibly contributing to the unusually high number of H3N2 infections in this season and providing important information for developing vaccines that are effective against both genotypes.
Starting Page	1505
Ending Page	1515
Page Count	11
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	161
Issue Number	6
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2016-03-14
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genetic analysis of HA1 domain of influenza A/H3N2 viruses isolated in Kenya during the 2007–2013 seasons reveal significant divergence from WHO-recommended vaccine strains

Genetic characterization of swine influenza viruses (H3N2) isolated from Minnesota in 2006–2007

Genetic analysis of H9N2 avian influenza viruses isolated from India

Phylogenetic analysis of swine influenza viruses recently isolated in Korea

Molecular analyses of H3N2 canine influenza viruses isolated from Korea during 2013–2014

Antigenic and genetic analysis of H5 influenza viruses isolated from water birds for the purpose of vaccine use

Sequence and phylogenetic analysis of H7N3 avian influenza viruses isolated from poultry in China in 2011

Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China

Molecular characterization of H3N2 influenza A viruses isolated from Ontario swine in 2011 and 2012

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains

Similar Documents

Genetic analysis of HA1 domain of influenza A/H3N2 viruses isolated in Kenya during the 2007–2013 seasons reveal significant divergence from WHO-recommended vaccine strains

Genetic characterization of swine influenza viruses (H3N2) isolated from Minnesota in 2006–2007

Genetic analysis of H9N2 avian influenza viruses isolated from India

Phylogenetic analysis of swine influenza viruses recently isolated in Korea

Molecular analyses of H3N2 canine influenza viruses isolated from Korea during 2013–2014

Antigenic and genetic analysis of H5 influenza viruses isolated from water birds for the purpose of vaccine use

Sequence and phylogenetic analysis of H7N3 avian influenza viruses isolated from poultry in China in 2011

Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China

Molecular characterization of H3N2 influenza A viruses isolated from Ontario swine in 2011 and 2012

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains