NDLI: Impact of IL-8-251A/T gene polymorphism on severity of disease caused by enterovirus 71 infection

Content Provider	Springer Nature Link
Author	Xu, Daoyan Li, Jian Huang, Xiangjuan Lin, Aiwei Gai, Zhongtao Chen, Zongbo
Copyright Year	2015
Abstract	The study was performed in EV71-infected patients, with 97 mild cases and 80 severe cases. IL-8251A/T genotypes were determined by the polymerase chain reaction restriction fragment length polymorphism technique. Severe cases had a significantly higher frequency of the IL8-251 AT and TT genotypes than mild cases (52.5 % vs. 49.5 % and 42.5 % vs. 30.9 %, respectively; p = 0.024). The frequency of IL-8-251T alleles among the severe cases was also significantly higher than that of mild cases (68.7 % vs. 55.7 %, OR = 1.8, 95 % CI = 1.1-2.7, p = 0.012). There were significant differences in gender, age, fever days, WBC, CRP and BG concentration, and IL-8 levels among genotypes of IL-8251A/T in EV71-infected patients, but there were no significant differences in ALT, AST, CK-MB and EV71 loads. These findings suggested that the IL-8-251T allele is associated with susceptibility to severe disease in Chinese patients infected with EV71.
Starting Page	203
Ending Page	207
Page Count	5
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	161
Issue Number	1
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2015-10-23
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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Impact of IL-8-251A/T gene polymorphism on severity of disease caused by enterovirus 71 infection