NDLI: Influenza A virus infection of mice induces nuclear accumulation of the tumorsuppressor protein p53 in the lung

Content Provider	Springer Nature Link
Author	Technau Ihling, K. Ihling, C. Kromeier, J. Brandner, G.
Copyright Year	2001
Abstract	To investigate whether the tumor suppressor p53 protein, an indicator of DNA damage and cell stress, accumulates in the course of influenza-virus-induced murine pneumonia at the site of inflammation, female BALB/c mice were infected each with 5 × 104 infectious units of influenza virus A, strain Puerto Rico (PR) 8, by instillation into the nose and the pharynx. Two days later the mice became sick. Three and 6 days after infection the lungs of sacrificed infected and uninfected mice were examined. We assessed the presence and localisation of inflammation, the expression of influenza viral and p53 protein, as well as of the WAF1/Cip1/SDI gene product p21. Further, the appearance of nitrotyrosine, as an indicator of the formation of peroxynitrite, and eventually of apoptotic cells was examined. No significant nuclear p53 accumulation was found in influenza virus-infected murine cells in vitro. The results show, that in the course of influenza A virus-mediated murine pneumonia inflammatory bystander cells may cause activation of the tumor suppressor protein p53, due to oxidative stress and DNA damage, with ensuing p53-dependent upregulation of p21. Apoptosis is then mainly due to these indirect processes, with possible involvement of p53.
Starting Page	1655
Ending Page	1666
Page Count	12
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	146
Issue Number	9
e-ISSN	14328798
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-09-01
Publisher Place	Wien
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A DNA vaccine expressing PB1 protein of influenza A virus protects mice against virus infection

Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection

Dengue virus infection induces formation of G3BP1 granules in human lung epithelial cells

Antibodies to PB1-F2 protein are induced in response to influenza A virus infection

Influenza B virus NS2, a nuclear export protein, directly associates with the viral ribonucleoprotein complex

Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors

Immunization with influenza A NP-expressing vaccinia virus recombinant protects mice against experimental infection with human and avian influenza viruses

Human infection by a swine influenza A (H1N1) virus in Switzerland

Influenza infection modulates vesicular trafficking and induces Golgi complex disruption

Influenza A virus infection of mice induces nuclear accumulation of the tumorsuppressor protein p53 in the lung

Similar Documents

A DNA vaccine expressing PB1 protein of influenza A virus protects mice against virus infection

Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection

Dengue virus infection induces formation of G3BP1 granules in human lung epithelial cells

Antibodies to PB1-F2 protein are induced in response to influenza A virus infection

Influenza B virus NS2, a nuclear export protein, directly associates with the viral ribonucleoprotein complex

Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors

Immunization with influenza A NP-expressing vaccinia virus recombinant protects mice against experimental infection with human and avian influenza viruses

Human infection by a swine influenza A (H1N1) virus in Switzerland

Influenza infection modulates vesicular trafficking and induces Golgi complex disruption

Influenza A virus infection of mice induces nuclear accumulation of the tumorsuppressor protein p53 in the lung