NDLI: Effect of two synthetic peptides mimicking conserved regions of equine infectious anemia virus proteins gp90 and gp45 upon cytokine mRNA expression

Content Provider	Springer Nature Link
Author	Bailat, Alejandra S. Soutullo, Adriana R. García, María I. Veaute, Carolina M. Garcia, Lucila Racca, Andrea L. Malan Borel, Ileana S.
Copyright Year	2008
Abstract	Gp90 and gp45 synthetic peptides, which mimic conserved sequences of native viral proteins, are recognized by antibodies to equine infectious anemia virus (EIAV) in asymptomatic carrier horses and generate humoral and cellular responses in immunized mice. Cytokine mRNA levels were evaluated in equine peripheral blood mononuclear cells (PBMCs) after in vitro stimulation with gp90 and gp45 with the aim of determining the cytokine profile associated with the proliferative response. Stimulation index (SI) values indicate that 100 and 60% of EIAV-infected horses recognized gp90 and gp45, respectively. A strong positive correlation was found between IL-12p40 and SI, IFN-γ and SI, and IL-12p40 and IFN-γ (p < 0.001). These results suggest the presence of specific memory cells that would contribute to maintain reinfection resistance and that conserved viral regions represented by gp90 and gp45 synthetic peptides may be good candidates for inclusion in vaccine strategies against EIAV.
Starting Page	1909
Ending Page	1915
Page Count	7
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	153
Issue Number	10
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2008-10-01
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infectious Diseases Medical Microbiology Virology
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Characterization of isolates of equine infectious anemia virus in Brazil

In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safety of an attenuated equine infectious anemia virus (EIAV) vaccine

Long terminal repeats are not the sole determinants of virulence for equine infectious anemia virus

Genomic comparison between attenuated Chinese equine infectious anemia virus vaccine strains and their parental virulent strains

Analysis of equine humoral immune responses to the transmembrane envelope glycoprotein (gp45) of equine infectious anemia virus.

Expression of a synthetic rust fungal virus cDNA in yeast

Glycoprotein G deletion mutants of equine herpesvirus 1 (EHV1; equine abortion virus) and EHV4 (equine rhinopneumonitis virus)

Unique evolution characteristics of the envelope protein of EIAV$_{LN40}$, a virulent strain of equine infectious anemia virus

Application of Equine Infectious Anemia Virus Core Proteins Produced in a Baculovirus Expression System to Serological Diagnosis

Effect of two synthetic peptides mimicking conserved regions of equine infectious anemia virus proteins gp90 and gp45 upon cytokine mRNA expression

Similar Documents

Characterization of isolates of equine infectious anemia virus in Brazil

In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safety of an attenuated equine infectious anemia virus (EIAV) vaccine

Long terminal repeats are not the sole determinants of virulence for equine infectious anemia virus

Genomic comparison between attenuated Chinese equine infectious anemia virus vaccine strains and their parental virulent strains

Analysis of equine humoral immune responses to the transmembrane envelope glycoprotein (gp45) of equine infectious anemia virus.

Expression of a synthetic rust fungal virus cDNA in yeast

Glycoprotein G deletion mutants of equine herpesvirus 1 (EHV1; equine abortion virus) and EHV4 (equine rhinopneumonitis virus)

Unique evolution characteristics of the envelope protein of EIAV$_{LN40}$, a virulent strain of equine infectious anemia virus

Application of Equine Infectious Anemia Virus Core Proteins Produced in a Baculovirus Expression System to Serological Diagnosis

Effect of two synthetic peptides mimicking conserved regions of equine infectious anemia virus proteins gp90 and gp45 upon cytokine mRNA expression