NDLI: Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks

Content Provider	Springer Nature Link
Author	Wasilenko, J. L. Arafa, A. M. Selim, A. A. Hassan, M. K. Aly, M. M. Ali, A. Nassif, S. Elebiary, E. Balish, A. Klimov, A. Suarez, D. L. Swayne, D. E. Pantin Jackwood, M. J.
Copyright Year	2010
Abstract	Domestic ducks have been implicated in the dissemination and evolution of H5N1 highly pathogenic avian influenza (HPAI) viruses. In this study, two H5N1 HPAI viruses belonging to clade 2.2.1 isolated in Egypt in 2007 and 2008 were analyzed for their pathogenicity in domestic Pekin ducks. Both viruses produced clinical signs and mortality, but the 2008 virus was more virulent, inducing early onset of neurological signs and killing all ducks with a mean death time (MDT) of 4.1 days. The 2007 virus killed 3/8 ducks with a MDT of 7 days. Full-genome sequencing and phylogenetic analysis were used to examine differences in the virus genes that might explain the differences observed in pathogenicity. The genomes differed in 49 amino acids, with most of the differences found in the hemagglutinin protein. This increase in pathogenicity in ducks observed with certain H5N1 HPAI viruses has implications for the control of the disease, since vaccinated ducks infected with highly virulent strains shed viruses for longer periods of time, perpetuating the virus in the environment and increasing the possibility of transmission to susceptible birds.
Starting Page	37
Ending Page	51
Page Count	15
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	156
Issue Number	1
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2010-09-30
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infectious Diseases Medical Microbiology Virology
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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