NDLI: High incidence of subclinical infection of lymphoid tissues in scrapie-affected sheep flocks

Content Provider	Springer Nature Link
Author	Georgsson, Gudmundur Adolfsdottir, Jona Adalheidur Palsdottir, Astridur Jorundsson, Einar Sigurdarson, Sigurdur Thorgeirsdottir, Stefania
Copyright Year	2008
Abstract	Prion diseases are characterized by a long incubation period. In scrapie, sheep may incubate and spread the infection for several years before clinical signs evolve. We have previously studied the occurrence of subclincal infection in the brain. Now, we have studied the occurrence of subclinical infection in the brain and several lymphoid tissues in two scrapie-affected Icelandic sheep flocks by immunohistochemistry for PrPSc, a molecular marker for infectivity, and correlated this with results of PrP genotyping. At culling, one flock had one confirmed scrapie case, while the other flock had two. Analysis of 106 asymptomatic sheep by immunostaining for PrPSc revealed that the incidence of subclinical infection was 58.3% in one flock and 42.5% in the other. PrPSc was only detected in lymphoid tissues. The youngest positive sheep were 4 months old. PrP genotyping showed that over 90% of the sheep were of a genotype which is moderately sensitive to infection and may delay neuroinvasion. Our results show that asymptomatic sheep may spread the infection during the long incubation period of several years, which constitutes an important obstacle in the eradication of scrapie. Our findings indicate that contamination of the environment plays an important part in sustaining the infection.
Starting Page	637
Ending Page	644
Page Count	8
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	153
Issue Number	4
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2008-01-29
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infectious Diseases Medical Microbiology Virology
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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PrPSc deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie

Isolation of two distinct prion strains from a scrapie-affected sheep

Ileal tract and Peyer’s patch innervation in scrapie-free versus scrapie-affected ovines

Comparative epidemiology of scrapie outbreaks in individual sheep flocks.

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PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie

Diagnosis and PrP genotype target of scrapie in clinically healthy sheep of Massese breed in the framework of a scrapie eradication programme

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High incidence of subclinical infection of lymphoid tissues in scrapie-affected sheep flocks

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PrPSc deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie

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