NDLI: Phylogenetic analysis of rabies virus isolated from canids in North and Northeast Brazil

Content Provider	Springer Nature Link
Author	Souza, Débora Nunes Carnieli, Pedro Macedo, Carla Isabel vaes Oliveira, Rafael Carvalho Ruthner Batista, Helena Beatriz Rodrigues, Adriana Candido Pereira, Patricia Maria Cruz Achkar, Samira Maria Vieira, Luiz Fernando Pereira Kawai, Juliana Galera Castilho
Copyright Year	2016
Abstract	Cases of canine rabies continue to occur in North and Northeast Brazil, and the number of notifications of rabies cases in wild canids has increased as a result of the expansion of urban areas at the expense of areas with native vegetation. In light of this, we performed molecular characterization of rabies virus isolates from dogs and Cerdocyon thous from various states in North and Northeast Brazil. In all, 102 samples from dogs (n = 56) and Cerdocyon thous (n = 46) collected between 2006 and 2012 were used. The nucleotide sequences obtained for the N gene of rabies virus were analyzed, and phylogenetic analysis revealed the presence of two distinct genetic lineages, one associated with canids and one with bats, and, within the canid cluster, two distinct sublineages circulating among dogs and Cerdocyon thous. In addition, phylogenetic groups associated with geographic region and fourteen cases of interspecific infection were observed among the isolates from canids. Our findings show that analysis of rabies virus lineages isolated from reservoirs such as canids must be constantly evaluated because the mutation rate is high.
Starting Page	71
Ending Page	77
Page Count	7
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	162
Issue Number	1
e-ISSN	14328798
Language	English
Publisher	Springer Vienna
Publisher Date	2016-09-26
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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