NDLI: Highly sensitive determination of doxorubicin and daunorubicin based on their effect on the resonance light scattering signals of the ethidium-DNA complex

Content Provider	Springer Nature Link
Author	Chen, Zhanguang Qian, Sihua Liu, Guoliang Chen, Xi Chen, Junhui
Copyright Year	2011
Abstract	We have developed a resonance light scattering (RLS) quenching assay for the highly sensitive determination of doxorubicin (DOX) and daunorubicin (DAU). It is based on the reduction of the intensity of the shoulder of the RLS spectra at 443 nm. The intensity of the RLS of the ethidium-DNA system decrease linearly on addition of trace quantities of DOX or DAU within the concentration range of 0.008 to 12.0 μg mL−1 for DOX, and of 0.010 to 21.0 μg mL−1 for DAU. The detection limits are 3.0 and 5.0 ng mL−1, respectively. The assay was successfully applied to the determination of DAU in synthetic and serum samples. Compared to the reported methods for anthracyclines, this assay displays higher sensitivity, lower detection limits, and a wider linear range. Graphical abstract The addition of trace amount of drugs into the EB-DNA system can induce the decreased RLS intensity of EB-DNA system at the shoulder peak in BR buffer solution (pH 2.0). Besides, the decrement of RLS intensities was proportional to the concentration of drugs. Based on this phenomenon, a new RLS assay for the detection of anthracycline antibiotics was developed.
Starting Page	217
Ending Page	223
Page Count	7
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	175
Issue Number	3-4
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2011-09-08
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Resonance light scattering (RLS) Shoulder peak Doxorubicin (DOX) Daunorubicin (DAU) DNA Analytical Chemistry Nanotechnology Nanochemistry Microengineering Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

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