NDLI: Ultra-high performance liquid chromatography combined with mass spectrometry for determination of aflatoxins using dummy molecularly imprinted polymers deposited on silica-coated magnetic nanoparticles

Content Provider	Springer Nature Link
Author	Tan, Lei He, Rong Chen, Kuncai Peng, Rongfei Huang, Cong Yang, Rong Tang, Youwen
Copyright Year	2016
Abstract	This article describes a method for determination of four aflatoxins by a combination of ultra-high performance liquid chromatography and mass spectrometry (UHPLC-MS/MS). Magnetic dummy molecularly imprinted polymers (md-MIPs) are used for fairly selective preconcentration. The preparation of the md-MIP involves (a) coating of magnetic nanoparticles (with a typical diameter of 200 nm) with a shell of silica, (b) modifying the surface with methacryloxy groups, and (c) creating a MIP on the surface by graft imprinting in aqueous solutions using 5,7-dimethoxycoumarin as the dummy template, and methacrylic acid and 4-vinylpyridine as the functional monomers. After elution of the template, the md-MIPs can be used for fairly selective extraction of the aflatoxins B1, B2, G1 and G2. Following magnetic separation of the particles, the aflatoxins were eluted and quantified by UHPLC-MS/MS. The limit of detection is 0.05 μg·kg−1 for aflatoxins B2 and G2, and 0.1 μg·kg−1 for aflatoxins B1 and G1. False-positive samples were identified by UHPLC-MS/MS in the positive ionization mode with multiple reaction monitoring. Graphical Abstract We describe a method for determination of four aflatoxins by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Determination of aflatoxins was accomplished by the magnetic dummy molecularly imprinted polymers, followed by a magnetic separation and subsequent quantification by UHPLC-MS/MS.
Starting Page	1469
Ending Page	1477
Page Count	9
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	183
Issue Number	4
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2016-02-16
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nanomaterial MIP Vibrating magnetometry Saturation magnetization Transmission electron microscopy Core-shell particles UHPLC-MS/MS FTIR Food analysis Nanochemistry Nanotechnology Characterization and Evaluation of Materials Analytical Chemistry Microengineering
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

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