NDLI: Electrochemical studies of calcium dobesilate and interaction with DNA

Content Provider	Springer Nature Link
Author	Xu, Hui Li, Xiaohong Zhang, Jingwei Zhang, Zhijun Liu, Kuaizhi
Copyright Year	2009
Abstract	The electrochemical behavior of calcium dobesilate (CD) and its interaction with DNA were explored using voltammetry and UV spectroscopy. The results show that CD could interact with DNA molecules by intercalation, forming a non-electroactive complex. CD has excellent electrochemical activity on a gold nanoparticle-modified glassy carbon electrode with a couple of redox peaks. In the presence of DNA, the peak current of CD decreases and the peak potential is shifted positively, but no new peak appears. The binding of CD with DNA, analyzed in terms of the cooperative Hill model, yields an association constant of 2.63 × 103 L·mol−1 and a Hill coefficient of m ≈ 2. These results may serve as a reference for in vivo investigation of the interaction of CD with DNA base pairs in living cells.
Starting Page	415
Ending Page	420
Page Count	6
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	165
Issue Number	3-4
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2009-03-31
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Calcium dobesilate Gold nanoparticles Modified electrode DNA interaction Ecotoxicology Characterization and Evaluation of Materials Physical Chemistry Inorganic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Electrochemical studies of calcium dobesilate and interaction with DNA