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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wang, Yong Hong Wu, Chun Hai Chu, Ju Hao, Yu You Zhuang, Ying Ping Zhang, Si Liang |
| Copyright Year | 2009 |
| Abstract | 4′′-O-isovalerylspiramycins are the major components of bitespiramycin complex consisting of a group of 4′′-O-acylated spiramycins. The availability of isovaleryl group, usually in vivo derived from leucine, one of the branched-chain amino acids, affects the content of isovaleryispiramycin significantly. In this study, the effect of glucose on the activity of branched-chain α-keto acid dehydrogenase (BCKDH), which catalyzed the rate-limiting as well as the first irreversible reaction oxidative decarboxylation for branched-chain amino acids degradation, and isovaleryispiramycin biosynthesis was investigated. In the initial glucose concentration experiment, when the residual glucose concentration in the medium declined to 2–4 g/L, the BCKDH activity rose rapidly, and glucose deprivation and the summit of BCKDH activity appeared nearly at the same time. After a delay of about 6 h, the maximal isovalerylspiramycin content was observed. However, the shortage of glucose at the later production phase resulted in the marked decrease in BCKDH activity and isovaleryispiramycin content. In the fermentation in a 50 L fermentor, glucose feeding at the late production phase helped to maintain the residual glucose concentration between 0 and 1 g/L, leading to the high level of BCKDH activity and thus isovalerylspiramycin content. These suggested that glucose concentration could be used as a key parameter to regulate BCKDH activity and isovaleryispiramycin biosynthesis in the bitespiramycin production. |
| Starting Page | 257 |
| Ending Page | 265 |
| Page Count | 9 |
| File Format | |
| ISSN | 16157591 |
| Journal | Bioprocess Engineering |
| Volume Number | 33 |
| Issue Number | 2 |
| e-ISSN | 16157605 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2009-05-05 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Bitespiramycin Component Isovalerylspiramycin Streptomyces Branched-chain amino acid Branched-chain α-keto acid dehydrogenase Industrial and Production Engineering Food Science Environmental Engineering/Biotechnology Biotechnology Industrial Chemistry/Chemical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Bioengineering Biotechnology |
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