NDLI: Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method

Content Provider	Springer Nature Link
Author	Sorouraddin, Mohammad Hossein Amini, Kaveh Naseri, Abdolhossein Asgari, Davoud Rashidi, Mohammad Reza
Copyright Year	2010
Abstract	Evaluation of metabolic pathways is one of the challenging areas in biological and pharmaceutical sciences. Phenanthridine oxidation to phenanthridinone is used commonly to study aldehyde oxidase activity. This reaction could pass through phenanthridine N-oxide intermediate. In the present study, the application of multivariate curve resolution, optimized by alternating least squares (MCR-ALS) to investigate this metabolic pathway has been described. The results obtained from MCR-ALS analysis along with those obtained from the use of potassium ferrocyanide method indicated that phenanthridine is directly oxidized to phenanthridinone by rat liver aldehyde oxidase without passing through phenanthridine N-oxide intermediate. It was also found that the later compound is not metabolized by this enzyme.
Starting Page	173
Ending Page	177
Page Count	5
File Format	PDF
ISSN	16157591
Journal	Bioprocess Engineering
Volume Number	34
Issue Number	2
e-ISSN	16157605
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-08-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Phenanthridine Phenanthridinone Phenanthridine N-oxide Aldehyde oxidase MCR-ALS Industrial and Production Engineering Food Science Environmental Engineering/Biotechnology Biotechnology Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Biotechnology

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