NDLI: Cybernetic modeling based on pathway analysis for Penicillium chrysogenum fed-batch fermentation

Content Provider	Springer Nature Link
Author	Geng, Jun Yuan, Jingqi
Copyright Year	2009
Abstract	A macrokinetic model employing cybernetic methodology is proposed to describe mycelium growth and penicillin production. Based on the primordial and complete metabolic network of Penicillium chrysogenum found in the literature, the modeling procedure is guided by metabolic flux analysis and cybernetic modeling framework. The abstracted cybernetic model describes the transients of the consumption rates of the substrates, the assimilation rates of intermediates, the biomass growth rate, as well as the penicillin formation rate. Combined with the bioreactor model, these reaction rates are linked with the most important state variables, i.e., mycelium, substrate and product concentrations. Simplex method is used to estimate the sensitive parameters of the model. Finally, validation of the model is carried out with 20 batches of industrial-scale penicillin cultivation.
Starting Page	665
Ending Page	674
Page Count	10
File Format	PDF
ISSN	16157591
Journal	Bioprocess Engineering
Volume Number	33
Issue Number	6
e-ISSN	16157605
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-06-19
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Penicillium chrysogenum Fed-batch fermentation Metabolic pathways Cybernetic modeling Industrial and Production Engineering Food Science Environmental Engineering/Biotechnology Biotechnology Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Biotechnology

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