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Comparison of a batch, fed-batch and continuously operated stirred-tank reactor for the enzymatic synthesis of (R)-mandelonitrile by using a process model

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Bioprocess Engineering : Volume 24, Issue 4, November 2001

Bioprocess Engineering : Volume 24, Issue 3, October 2001

Bioprocess Engineering : Volume 24, Issue 2, September 2001

Bioprocess Engineering : Volume 24, Issue 1, August 2001

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Bioprocess Engineering : Volume 18

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Bioprocess Engineering : Volume 16

Comparison of a batch, fed-batch and continuously operated stirred-tank reactor for the enzymatic synthesis of (R)-mandelonitrile by using a process model

Content Provider	Springer Nature Link
Author	Willeman, W. F. Straathof, A. J. J. Heijnen, J. J.
Copyright Year	2001
Abstract	The suitability of a batch, fed-batch and continuously operated stirred-tank reactor for the enzymatic production of (R)-mandelonitrile in an aqueous-organic biphasic system was investigated by using a process model. The considered biphasic system is 10–50% (v/v) 100 mM sodium citrate buffer of pH 5.5 dispersed in methyl tert-butyl ether. The constraints were that 750 moles of benzaldehyde per cubic meter should react towards (R)-mandelonitrile with an enantiomeric excess of 99% and a conversion of 98%. A continuously operated stirred-tank reactor could not meet the constraints, but the production in a batch or fed-batch reactor was feasible. The choice for a batch or fed-batch reactor is dependent on the influence of the costs for reactor operation and for the enzyme on the product costs. The choice for operating at a small or large aqueous-phase volume fraction is dependent on the costs and reusability of the enzyme. The volumetric productivity is maximal when operating as batch. The enzymatic productivity and turnover are maximal when operating as fed batch. In the fed-batch mode, the enzymatic productivity increased by 24–37%, the turnover increased by 50–60% and the volumetric productivity decreased by 33–71% as compared to a batch reactor. By enhancement of mass transfer both the volumetric and enzymatic productivity can be increased considerably, while the turnover is only slightly decreased.
Starting Page	281
Ending Page	287
Page Count	7
File Format	PDF
ISSN	16157591
Journal	Bioprocess Engineering
Volume Number	24
Issue Number	5
e-ISSN	16157605
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-12-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biotechnology Industrial and Production Engineering Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering Food Science
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Biotechnology

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