NDLI: Kinetic models of ribonucleic acid fermentation and continuous culture by Candida tropicalis no.121

Content Provider	Springer Nature Link
Author	Li, Bingbing Chen, Xiaochun Ren, Huajing Li, Lei Xiong, Jian Bai, Jianxin Chen, Yong Wu, Jinglan Ying, Hanjie
Copyright Year	2011
Abstract	During ribonucleic acid fermentation, the fermentative processes were researched at pH controlled at 4.0 and under natural conditions. Unstructured models in a 50-L airlift fermentor were established for batch RNA production at pH 4.0 using the Verhulst equation for microbial growth, the Luedeking–Piret equation for product formation and a Luedeking–Piret-like equation for substrate uptake. Parameters of the kinetic models were determined using origin 7.5. Based on the models estimated above, another batch fermentation experiment was conducted in a 300-L airlift fermentor, which demonstrated that the models could be useful for RNA production on an industrial scale. Additionally, continuous fermentation based on kinetic models was proposed to make full use of substrates and reduce the cost of waste water treatment. As a result, although the DCW and RNA concentration were 11.5 and 1.68 g L−1, which were lower than that of batch fermentation, the sugar utilization increased by 14.3%, while the waste water decreased by more than 90%.
Starting Page	415
Ending Page	422
Page Count	8
File Format	PDF
ISSN	16157591
Journal	Bioprocess Engineering
Volume Number	35
Issue Number	3
e-ISSN	16157605
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-08-19
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Candida tropicalis no.121 Continuous fermentation Kinetic model Ribonucleic acid Industrial Chemistry/Chemical Engineering Environmental Engineering/Biotechnology Industrial and Production Engineering Food Science Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Biotechnology

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