NDLI: Characteristics of resident dendritic cells in various regions of rat periodontal ligament

Content Provider	Springer Nature Link
Author	Kaneko, Tomoatsu Okiji, Takashi Kaneko, Reika Suda, Hideaki
Copyright Year	2007
Abstract	In the periodontal ligament (PDL) of normal rat molars, a considerable number of dendritic cells (DCs) are distributed as resident immunocompetent cells. We have hypothesized that the resident type of DCs can alter their morphology and phenotype to adapt to the microenvironment of the PDL. Thus, we have compared the characteristics of DCs in various regions of rat PDL by immunoelectron microscopy and gene expression analysis by means of reverse transcription/polymerase chain reaction. DCs in the periapical region show immature characteristics, i.e., small round profiles and few organelles. In the mesial region, which is the most stable area in the PDL, the density of DCs is the highest. DCs in the furcal region show the characteristics of activated antigen-presenting cells, i.e., CD86high expression, electron-dense lysosomes, and cell-to-cell contacts with lymphocytes. When the PDL is bacterially challenged by pulp exposure, the number of CD86+ DCs and contacts with lymphocytes increase in the furcal region. Gene expression analysis for the furcal region has also shown the up-regulation of the major histocompatibility complex class II alpha-chain, CD83, CD86, and the antigen-presenting cell-lectin-like receptor A1. Thus, we have demonstrated heterogeneity in resident DCs. This may be associated with the difference in DCs regarding their state of maturation/activation, which may further reflect microenvironmental differences such as the amount of external antigens.
Starting Page	413
Ending Page	421
Page Count	9
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	331
Issue Number	2
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-11-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dendritic cell CD86 MHC class II Immunoelectron microscopy Periodontal ligament Rat Molecular Medicine Proteomics Human Genetics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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