NDLI: Trps1 is necessary for normal temporomandibular joint development

Content Provider	Springer Nature Link
Author	Michikami, Ikumi Fukushi, Toshiya Honma, Shiho Yoshioka, Seisuke Itoh, Shunji Muragaki, Yasuteru Kurisu, Kojiro Ooshima, Takashi Wakisaka, Satoshi Abe, Makoto
Copyright Year	2012
Abstract	Mutation of the human TRPS1 gene leads to trichorhinophalangeal syndrome (TRPS), which is characterized by an abnormal development of various organs including the craniofacial skeleton. Trps1 has recently been shown to be expressed in the jaw joints of zebrafish; however, whether Trps1 is expressed in the mammalian temporomandibular joint (TMJ), or whether it is necessary for TMJ development is unknown. We have analyzed (1) the expression pattern of Trps1 during TMJ development in mice and (2) TMJ development in Trps1 knockout animals. Trps1 is expressed in the maxillo-mandibular junction at embryonic day (E) 11.5. At E15.5, expression is restricted to the developing condylar cartilage and to the surrounding joint disc progenitor cells. In Trps1 knockout mice, the glenoid fossa of the temporal bone forms relatively normally but the condylar process is extremely small and the joint disc and cavities do not develop. The initiation of condyle formation is slightly delayed in the mutants at E14.5; however, at E18.5, the flattened chondrocyte layer is narrowed and most of the condylar chondrocytes exhibit precocious chondrocyte maturation. Expression of Runx2 and its target genes is expanded toward the condylar apex in the mutants. These observations underscore the indispensable role played by Trps1 in normal TMJ development in supporting the differentiation of disc and synoviocyte progenitor cells and in coordinating condylar chondrocyte differentiation.
Starting Page	131
Ending Page	140
Page Count	10
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	348
Issue Number	1
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-03-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TRPS1 Temporomandibular Disc Runx2 Mouse Human Genetics Molecular Medicine Proteomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice

Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage

Runx2 acts downstream of C/EBPβ to regulate the differentiation of uterine stromal cells in mice

Regulation of bone development and extracellular matrix protein genes by RUNX2

SNAREs during development

Mouse CD24 is required for homeostatic cell renewal

Apoptosis in cardiac development

Endothelial cell biology and pathology

Epigenetics: development, dynamics and disease

Trps1 is necessary for normal temporomandibular joint development

Similar Documents

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice

Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage

Runx2 acts downstream of C/EBPβ to regulate the differentiation of uterine stromal cells in mice

Regulation of bone development and extracellular matrix protein genes by RUNX2

SNAREs during development

Mouse CD24 is required for homeostatic cell renewal

Apoptosis in cardiac development

Endothelial cell biology and pathology

Epigenetics: development, dynamics and disease

Trps1 is necessary for normal temporomandibular joint development