NDLI: TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion

Content Provider	Springer Nature Link
Author	Hisanaga, Takuro Terai, Shuji Iwamoto, Takuya Takami, Taro Yamamoto, Naoki Murata, Tomoaki Matsuyama, Toshifumi Nishina, Hiroshi Sakaida, Isao
Copyright Year	2011
Abstract	The importance of TNF-α signals mediated by tumor necrosis factor receptor type 1 (TNFR1) in inflammation and fibrosis induced by carbon tetrachloride (CCl4), and in post-injury liver regeneration including a GFP/CCl4 model developed as a liver repair model by bone marrow cell (BMC) infusion, was investigated. In mice in which TNFR1 was suppressed by antagonist administration or by knockout, liver fibrosis induced by CCl4 was significantly decreased. In these mice, intrahepatic macrophage infiltration and TGF-β1 expression were reduced and stellate cell activity was decreased; however, expression of MMP-9 was also decreased. With GFP-positive BMC (TNFR1 wild-type, WT) infusion in these mice, fibrosis proliferation, including host endogenous intrahepatic macrophage infiltration, TGF-β1 expression and stellate cell activity, increased significantly. There was no significant increase of MMP-9 expression. In this study, TNFR1 in hosts had a promoting effect on CCl4-induced hepatotoxicity and fibrosis, whereas BMC infusion in TNFR1 knockout mice enhanced host-derived intrahepatic inflammation and fibrosis proliferation. These findings differed from those in WT recipient mice, in which improvement in inflammation and fibrosis with BMC infusion had previously been reported. TNFR1-mediated signaling might be important to induce the improvement of liver fibrosis by bone marrow cell infusion.
Starting Page	79
Ending Page	88
Page Count	10
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	346
Issue Number	1
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-10-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tumor necrosis factor CCl4 Bone marrow cell Liver cirrhosis Hepatic stellate cell Human Genetics Proteomics Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion

TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion

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TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion

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TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion

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TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion