NDLI: Persistent activation of omentum influences the pattern of muscular lesion in the mdx diaphragm

Content Provider	Springer Nature Link
Author	Pinheiro, Douglas Florindo Silva, Rafael F. Carvalho, Lian P. Paiva Oliveira, Eustaquio L. Pereira, Ricardo S. Leite, Paulo Emilio C. de Fátima Pinho, Maria Quirico Santos, Thereza Lagrota Candido, Jussara
Copyright Year	2012
Abstract	The mdx (X chromosome-linked muscular dystrophy) mouse develops a multi-staged disorder characterized by muscle degeneration and reactive fibrosis. Skeletal muscles of mdx mice are not equally susceptible to degeneration. The aim of this study was to verify whether the intense remodeling of the mdx diaphragm could be attributed to influences from the peritoneal microenvironment and omentum, a lymphohematopoietic tissue rich in progenitor cells and trophic factors. At ages corresponding to increased muscular regeneration (12 weeks) and activation of fibrosis (24 weeks), the mdx omentum exhibited (1) morphological and functional characteristics of activation with enlarged milk-spots, an accumulation of CD4+, CD8+ and CD19+B220+ B lymphocytes; (2) the formation of clusters positive for proliferating cell nuclear antigen, mainly in B220+-rich areas organized in a follicular structure with a germinative center without any challenge by external antigen inducers; (3) clusters with cells positive for fibroblast growth factor-2, numerous Sca-1+CD3-CD19-Mac-1- progenitor cells and increased CD4+, CD8+ and CD3+NK1.1+ cells in the peritoneal cavity. Omentectomy reduced areas with F4/80+ inflammatory infiltrate the activity of matrix metalloproteases 9 and 2, collagen deposition and areas with regenerating myofibers in the diaphragm. Thus, persistent activation of the omentum influences the pattern of inflammation and regeneration of the mdx diaphragm partly via the activation of progenitor cells and the production of growth factors that influence the physiopathology of the muscular tissue remodeling.
Starting Page	77
Ending Page	88
Page Count	12
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	350
Issue Number	1
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-06-13
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Muscular dystrophy (mdx) Omentum Diaphragm Peritoneal cavity Mouse Molecular Medicine Human Genetics Proteomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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