NDLI: Molecular architecture and function of the hemidesmosome

Content Provider	Springer Nature Link
Author	Walko, Gert Castañón, Maria J. Wiche, Gerhard
Copyright Year	2014
Abstract	Hemidesmosomes are multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. The mechanical stability of hemidesmosomes relies on multiple interactions of a few protein components that form a membrane-embedded tightly-ordered complex. The core of this complex is provided by integrin α6β4 and P1a, an isoform of the cytoskeletal linker protein plectin that is specifically associated with hemidesmosomes. Integrin α6β4 binds to the extracellular matrix protein laminin-332, whereas P1a forms a bridge to the cytoplasmic keratin intermediate filament network. Other important components are BPAG1e, the epithelial isoform of bullous pemphigoid antigen 1, BPAG2, a collagen-type transmembrane protein and CD151. Inherited or acquired diseases in which essential components of the hemidesmosome are missing or structurally altered result in tissue fragility and blistering. Modulation of hemidesmosome function is of crucial importance for a variety of biological processes, such as terminal differentiation of basal keratinocytes and keratinocyte migration during wound healing and carcinoma invasion. Here, we review the molecular characteristics of the proteins that make up the hemidesmosome core structure and summarize the current knowledge about how their assembly and turnover are regulated by transcriptional and post-translational mechanisms.
Starting Page	363
Ending Page	378
Page Count	16
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	360
Issue Number	2
e-ISSN	14320878
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-12-09
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hemidesmosomes Plectin Integrin Bullous pemphigoid antigen Epidermolysis bullosa Human Genetics Proteomics Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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Molecular architecture and function of the hemidesmosome

Molecular architecture and function of the hemidesmosome

Molecular architecture and function of the hemidesmosome

Blistering disease: insight from the hemidesmosome and other components of the dermal-epidermal junction

Analysis of the interactions between BP180, BP230, plectin and the integrin α6β4 important for hemidesmosome assembly

Keratins and skin disease

Hemidesmosome Formation Is Initiated by the β4 Integrin Subunit, Requires Complex Formation of β4 and HD1/Plectin, and Involves a Direct Interaction between β4 and the Bullous Pemphigoid Antigen 180

Inherited epidermolysis bullosa

Hemidesmosome Formation Is Initiated by the β4 Integrin Subunit, Requires Complex Formation of β4 and HD1/Plectin, and Involves a Direct Interaction between β4 and the Bullous Pemphigoid Antigen 180

Molecular architecture and function of the hemidesmosome

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Molecular architecture and function of the hemidesmosome

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Analysis of the interactions between BP180, BP230, plectin and the integrin α6β4 important for hemidesmosome assembly

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Molecular architecture and function of the hemidesmosome