NDLI: Distribution of the collagen-binding integrin α10β1 during mouse development

Content Provider	Springer Nature Link
Author	Camper, Lisbet Holmvall, Karin Wängnerud, Christel Aszódi, Attila Lundgren Åkerlund, Evy
Copyright Year	2001
Abstract	We have previously identified and characterised the collagen type II-binding integrin subunit α10, which is a member of the β1 family and is expressed by chondrocytes. In the present study, we examined the expression of the α10 integrin in various mouse tissues. Immunohistochemical analysis of α10 on cryosections from 3-day-old mice demonstrated that α10β1 was present in the hyaline cartilage of joints, vertebral column, trachea and bronchi. In addition, α10 was found in the ossification groove of Ranvier, in the aortic and atrioventricular valves of the heart and in the fibrous tissue lining skeletal muscle and ligaments. Overall, the distribution was distinct from that of the collagen-binding integrins α1β1 and α2β1. We also found that α10β1was the dominating collagen-binding integrin during cartilage development. Expression of α10 appeared at embryonic day 11.5 (E11.5) at the same time as chondrogenesis started as judged by collagen type II expression. At E13.5, α10 was present throughout the anlage as well as in the perichondrium and in mesenchyme just outside the perichondrium, where it localised with collagen type I. Four weeks after birth, α10 was prominent both at the articular surface and in the growth plate. In conclusion, we found that integrin α10β1 was a major collagen-binding integrin during cartilage development and in mature hyaline cartilage. In addition, we found that α10β1 was present in some fibrous tissues.
Starting Page	107
Ending Page	116
Page Count	10
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	306
Issue Number	1
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-08-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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