NDLI: Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney

Content Provider	Springer Nature Link
Author	Lee, Hyun Wook Qin, Yan Xia Kim, Yu Mi Park, Eun Young Hwang, Jin Sun Huo, Guan Hua Yang, Chul Woo Kim, Wan Young Kim, Jin
Copyright Year	2010
Abstract	Our knowledge of the embryonic development of the lymphatic vessels within the kidney is limited. The aim of this study was to establish the time of appearance and the distribution of intra-renal lymphatic vessels in the developing mouse kidney by using the lymphatic marker, LYVE-1. Kidneys from embryonic day 12 (E12) to E18, from neonates at post-natal day 1 (P1) to P21, and from adults were studied. In the adult mouse kidney, LYVE-1 was expressed mainly in the lymphatic endothelial cells (LECs) and in a subset of endothelial cells in the glomerular capillaries. However, in the developing mouse kidney, LYVE-1 was also expressed transiently in F4/80+/CD11b– immature macrophages/dendritic cells and in the developing renal vein. LYVE-1+ lymphatic vessels connected with extra-renal lymphatics were detected in the kidney at E13. F4/80+/CD11b–/LYVE-1+ immature macrophages/dendritic cells appeared prior to the appearance of LYVE-1+ renal lymphatic vessels and were closely intermingled or even formed part of the lymphatic vascular wall. Prox1 was expressed only in the LYVE-1+ LECs from fetus to adult-hood, but not in LYVE-1+ endothelial cells of the developing renal vein and macrophages/dendritic cells. Thus, lymphatic vessels of the kidney might originate by extension of extra-renal lymphatics through an active branching process possibly associated with F4/80+/CD11b–/LYVE-1+ macrophages/dendritic cells.
Starting Page	429
Ending Page	444
Page Count	16
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	343
Issue Number	2
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-12-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	LYVE-1 Lymphangiogenesis Kidney Mouse (C57BL/6) Molecular Medicine Proteomics Human Genetics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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